WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531775
CAS#: 751462-86-9 (free base)
Description: EGIS-7625 is a selective and competitive 5-HT2B receptor antagonist.
Hodoodo Cat#: H531775
Name: EGIS-7625
CAS#: 751462-86-9 (free base)
Chemical Formula: C18H22N4O2
Exact Mass: 326.17
Molecular Weight: 326.400
Elemental Analysis: C, 66.24; H, 6.79; N, 17.17; O, 9.80
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Related CAS #: 751462-86-9 (free base) 755040-97-2 (hydrochloride)
Synonym: EGIS-7625; EGIS 7625; EGIS7625.
IUPAC/Chemical Name: 5-(4-benzylpiperazin-1-yl)-2-methyl-4-nitroaniline
InChi Key: ZEFXWOMFCPRXJW-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H22N4O2/c1-14-11-18(22(23)24)17(12-16(14)19)21-9-7-20(8-10-21)13-15-5-3-2-4-6-15/h2-6,11-12H,7-10,13,19H2,1H3
SMILES Code: Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 326.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kovács A, Gacsályi I, Wellmann J, Schmidt E, Szücs Z, Dubreuil V, Nicolas JP, Boutin J, Bózsing D, Egyed A, Tihanyi K, Spedding M, Szénási G. Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist. Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):427-34. PubMed PMID: 15107597.