WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529417
CAS#: 205187-53-7
Description: TriRima, also known as CX-157, is a monoamine oxidase (MAO) -A inhibitor potentially for the treatment of depression and anxiety.
Hodoodo Cat#: H529417
Name: TriRima
CAS#: 205187-53-7
Chemical Formula: C14H8F4O4S
Exact Mass: 348.01
Molecular Weight: 348.260
Elemental Analysis: C, 48.28; H, 2.32; F, 21.82; O, 18.38; S, 9.21
This product is not in stock, which may be available by custom synthesis.
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Synonym: CX-157; CX157; CX 157; TriRima; Tyrima;
IUPAC/Chemical Name: 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
InChi Key: PDIMOTRDGUQMNY-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H8F4O4S/c15-8-1-3-12-10(5-8)22-11-6-9(21-7-14(16,17)18)2-4-13(11)23(12,19)20/h1-6H,7H2
SMILES Code: FC(F)(F)COC1=CC(OC2=CC(F)=CC=C2S3(=O)=O)=C3C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 348.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Fowler JS, Logan J, Azzaro AJ, Fielding RM, Zhu W, Poshusta AK, Burch D, Brand B, Free J, Asgharnejad M, Wang GJ, Telang F, Hubbard B, Jayne M, King P, Carter P, Carter S, Xu Y, Shea C, Muench L, Alexoff D, Shumay E, Schueller M, Warner D, Apelskog-Torres K. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31. doi: 10.1038/npp.2009.167. PubMed PMID: 19890267; PubMed Central PMCID: PMC2833271.
2: Burch D, Asgharnejad M, Gerson W, Fielding RM, Azzaro AJ. Lack of tyramine pressor response effect with oral CX157: A specific reversible MAOI. Clin Pharmacol Drug Dev. 2014 Jan;3(1):4-12. doi: 10.1002/cpdd.61. PubMed PMID: 27128224.
3: Targum SD, Burch DJ, Asgharnejad M, Petersen T, Gomeni R, Fava M. Use of band-pass filter analysis to evaluate outcomes in an antidepressant trial for treatment resistant patients. Eur Neuropsychopharmacol. 2014 Aug;24(8):1188-95. doi: 10.1016/j.euroneuro.2014.06.003. PubMed PMID: 25012515.
4: Targum SD, Pendergrass JC, Toner C, Asgharnejad M, Burch DJ. Audio-digital recordings used for independent confirmation of site-based MADRS interview scores. Eur Neuropsychopharmacol. 2014 Nov;24(11):1760-6. doi: 10.1016/j.euroneuro.2014.08.016. PubMed PMID: 25239474.