Foxy-5

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H527718

CAS#: 881188-51-8

Description: Foxy-5 is a wnt signalling pathway modulator potentially forthe treatment of metastatic breast cancer, prostate cancer and colorectal cancer. In vitro analyses revealed that both recombinant Wnt-5a and the Wnt-5a-derived Foxy-5 peptide impaired migration and invasion without affecting apoptosis or proliferation of 4T1 breast cancer cells. The in vivo experiments show that i.p. injections of Foxy-5 inhibited metastasis of inoculated 4T1 breast cancer cells from the mammary fat pad to the lungs and liver by 70% to 90%.

Chemical Structure

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Foxy-5
CAS# 881188-51-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H527718
Name: Foxy-5
CAS#: 881188-51-8
Chemical Formula: C26H42N6O12S2
Exact Mass: 694.23
Molecular Weight: 694.772
Elemental Analysis: C, 44.95; H, 6.09; N, 12.10; O, 27.63; S, 9.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Foxy-5; Foxy 5; Foxy5

IUPAC/Chemical Name: (2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecanedioic acid

InChi Key: WFZPJYYCTSHDJI-ATIWLJMLSA-N

InChi Code: InChI=1S/C26H42N6O12S2/c1-13(2)8-17(26(43)44)32-24(41)15(4-5-20(35)36)30-25(42)18(11-45)29-19(34)10-27-22(39)16(9-21(37)38)31-23(40)14(28-12-33)6-7-46-3/h12-18,45H,4-11H2,1-3H3,(H,27,39)(H,28,33)(H,29,34)(H,30,42)(H,31,40)(H,32,41)(H,35,36)(H,37,38)(H,43,44)/t14-,15-,16-,17-,18-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@H](CCSC)NC=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 694.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ford CE, Ekström EJ, Howlin J, Andersson T. The WNT-5a derived peptide, Foxy-5, possesses dual properties that impair progression of ERalpha negative breast cancer. Cell Cycle. 2009 Jun 15;8(12):1838-42. Review. Retraction in: Andersson T, Ford CE, Ekström EJ, Howlin J. Cell Cycle. 2011 Apr 1;10(7):1167. PubMed PMID: 19448401.

2: Säfholm A, Tuomela J, Rosenkvist J, Dejmek J, Härkönen P, Andersson T. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res. 2008 Oct 15;14(20):6556-63. doi: 10.1158/1078-0432.CCR-08-0711. PubMed PMID: 18927296.

3: Andersson T, Ford CE, Ekström EJ, Howlin J. Retracted manuscript: The WNT-5a derived peptide, Foxy-5, possesses dual properties that impair progression of ERα negative breast cancer. Cell Cycle. 2011 Apr 1;10(7):1167. PubMed PMID: 21430443.

4: Mehdawi LM, Prasad CP, Ehrnström R, Andersson T, Sjölander A. Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells. Mol Oncol. 2016 Nov;10(9):1415-1429. doi: 10.1016/j.molonc.2016.07.011. PubMed PMID: 27522468.

5: Varela-Nallar L, Parodi J, Farías GG, Inestrosa NC. Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity. Neurodegener Dis. 2012;10(1-4):23-6. doi: 10.1159/000333360. Review. PubMed PMID: 22261402.

6: Ford CE, Ekström EJ, Andersson T. Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3919-24. doi: 10.1073/pnas.0809516106. Retraction in: Ford CE, Ekström EJ, Anderson T. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22360. PubMed PMID: 19237581; PubMed Central PMCID: PMC2656180.

7: Compton DM, Dietrich KL, Selinger MC, Testa EK. 5-methoxy-N,N-di(iso)propyltryptamine hydrochloride (Foxy)-induced cognitive deficits in rat after exposure in adolescence. Physiol Behav. 2011 May 3;103(2):203-9. doi: 10.1016/j.physbeh.2011.01.021. PubMed PMID: 21295050.