GSK-264220A
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H531881

CAS#: 685506-42-7

Description: GSK-264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).


Chemical Structure

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GSK-264220A
CAS# 685506-42-7

Theoretical Analysis

Hodoodo Cat#: H531881
Name: GSK-264220A
CAS#: 685506-42-7
Chemical Formula: C17H21N3O4S
Exact Mass: 363.13
Molecular Weight: 363.432
Elemental Analysis: C, 56.18; H, 5.82; N, 11.56; O, 17.61; S, 8.82

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 600 2 Weeks
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Synonym: GSK-264220A; GSK 264220A; GSK264220A.

IUPAC/Chemical Name: 3-[2-methyl-5-(piperidine-1-sulfonyl)furan-3-yl]-1-phenylurea

InChi Key: LVOVQRPAMXCXTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21N3O4S/c1-13-15(19-17(21)18-14-8-4-2-5-9-14)12-16(24-13)25(22,23)20-10-6-3-7-11-20/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,18,19,21)

SMILES Code: O=C(NC1=C(C)OC(S(=O)(N2CCCCC2)=O)=C1)NC3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Goodman et al (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts. 19 27.