WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531881
CAS#: 685506-42-7
Description: GSK-264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).
Hodoodo Cat#: H531881
Name: GSK-264220A
CAS#: 685506-42-7
Chemical Formula: C17H21N3O4S
Exact Mass: 363.13
Molecular Weight: 363.432
Elemental Analysis: C, 56.18; H, 5.82; N, 11.56; O, 17.61; S, 8.82
Synonym: GSK-264220A; GSK 264220A; GSK264220A.
IUPAC/Chemical Name: 3-[2-methyl-5-(piperidine-1-sulfonyl)furan-3-yl]-1-phenylurea
InChi Key: LVOVQRPAMXCXTM-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H21N3O4S/c1-13-15(19-17(21)18-14-8-4-2-5-9-14)12-16(24-13)25(22,23)20-10-6-3-7-11-20/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,18,19,21)
SMILES Code: O=C(NC1=C(C)OC(S(=O)(N2CCCCC2)=O)=C1)NC3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 363.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Goodman et al (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts. 19 27.