UR-13870

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H527904

CAS#: 755753-89-0

Description: UR-13870 is a p38 mitogen-activated protein kinase (MAPK) inhibitor potentially for the treatment of autoimmune disease and neuropathic pain. UR-13870 treatment significantly reduced OX-42, metabotropic glutamate type 5 receptor (mGluR5), and NMDA (N-methyl-d-aspartate) 2B subunit receptor (NR2B) expression in the anterior cingulate cortex after spinal cord injury. UR-13870 treatment significantly decreased hindlimb hyperreflexia to both mechanical and cold stimuli after spared nerve injury without loss of general motor function, in addition to a reduction in pain-related anxiety behavior at day 21 after spared nerve injury, accompanied by normalization of OX-42 immunoreactivity within the ipsilateral lumbar dorsal horn.

Chemical Structure

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UR-13870
CAS# 755753-89-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H527904
Name: UR-13870
CAS#: 755753-89-0
Chemical Formula: C24H16F2N4
Exact Mass: 398.13
Molecular Weight: 398.417
Elemental Analysis: C, 72.35; H, 4.05; F, 9.54; N, 14.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: UR-13870, UR 13870, UR13870

IUPAC/Chemical Name: 4,6-bis(4-fluorophenyl)-2-methyl-5-(pyridin-4-yl)-2H-pyrazolo[3,4-b]pyridine

InChi Key: VMAKTIDYMSNPOV-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H16F2N4/c1-30-14-20-21(15-2-6-18(25)7-3-15)22(16-10-12-27-13-11-16)23(28-24(20)29-30)17-4-8-19(26)9-5-17/h2-14H,1H3

SMILES Code: CN1N=C2C(C(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)C(C5=CC=C(F)C=C5)=N2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 398.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Galan-Arriero I, Avila-Martin G, Ferrer-Donato A, Gomez-Soriano J, Bravo-Esteban E, Taylor J. Oral administration of the p38α MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury. Pain. 2014 Oct;155(10):2188-98. doi: 10.1016/j.pain.2014.08.030. PubMed PMID: 25180015.

2: Galan-Arriero I, Avila-Martin G, Ferrer-Donato A, Gomez-Soriano J, Piazza S, Taylor J. Early treatment with UR13870, a novel inhibitor of p38α mitogenous activated protein kinase, prevents hyperreflexia and anxiety behaviors, in the spared nerve injury model of neuropathic pain. Neurosci Lett. 2015 Sep 14;604:69-74. doi: 10.1016/j.neulet.2015.07.044. PubMed PMID: 26240995.

3: Mihara K, Almansa C, Smeets RL, Loomans EE, Dulos J, Vink PM, Rooseboom M, Kreutzer H, Cavalcanti F, Boots AM, Nelissen RL. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64. doi: 10.1038/bjp.2008.53. PubMed PMID: 18297096; PubMed Central PMCID: PMC2438984.