WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H528003
CAS#: 123288-47-1
Description: ONO-8809 is a thromboxane A2 receptor antagonist potentially for the treatment of stroke. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner, but not the airway wall thickening induced by LTC4, suggesting that the effect of LTC4 on bronchial hyperresponsiveness is likely to be mediated through TXA2. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area in the contralateral cerebral cortex to the stroke lesion of salt-loaded SHRSP and 8-iso-PGF2alpha-treated SHRSP were significantly reduced by ONO-8809 treatment.
Hodoodo Cat#: H528003
Name: ONO-8809
CAS#: 123288-47-1
Chemical Formula: C30H46BrNO4S
Exact Mass: 595.23
Molecular Weight: 596.665
Elemental Analysis: C, 60.39; H, 7.77; Br, 13.39; N, 2.35; O, 10.73; S, 5.37
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Synonym: ONO-8809; ONO 8809; ONO8809
IUPAC/Chemical Name: decyl (Z)-6-((1S,2S,3R,4R)-3-(((4-bromophenyl)sulfonamido)methyl)bicyclo[2.2.1]heptan-2-yl)hex-5-enoate
InChi Key: KLMMNRLRCVRTDN-IVMBPFMGSA-N
InChi Code: InChI=1S/C30H46BrNO4S/c1-2-3-4-5-6-7-8-12-21-36-30(33)14-11-9-10-13-28-24-15-16-25(22-24)29(28)23-32-37(34,35)27-19-17-26(31)18-20-27/h10,13,17-20,24-25,28-29,32H,2-9,11-12,14-16,21-23H2,1H3/b13-10-/t24-,25+,28+,29+/m0/s1
SMILES Code: O=C(OCCCCCCCCCC)CCC/C=C\[C@@H]1[C@@](C2)([H])CC[C@@]2([H])[C@H]1CNS(=O)(C3=CC=C(Br)C=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 596.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ishizuka T, Niwa A, Tabuchi M, Nagatani Y, Ooshima K, Higashino H. Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded, stroke-prone rats. J Hypertens. 2007 Apr;25(4):861-70. PubMed PMID: 17351380.
2: Kurosawa M, Yodonawa S, Tsukagoshi H. Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. Clin Exp Allergy. 1993 Oct;23(10):843-50. PubMed PMID: 10780891.
3: Nagata T, Uehara Y, Hara K, Igarashi K, Hazama H, Hisada T, Kimura K, Goto A, Omata M. Thromboxane inhibition and monocrotaline-induced pulmonary hypertension in rats. Respirology. 1997 Dec;2(4):283-9. PubMed PMID: 9525298.
4: Wakitani K, Matsumoto R, Imawaka H, Kamanaka Y, Naka M, Hamanaka N, Okegawa T, Kawasaki A. Anti-thrombotic effect of ONO-8809, a novel TXA2/PG endoperoxide receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:599-602. PubMed PMID: 1825384.
5: Zhou MS, Nishida Y, Chen QH, Kosaka H. Endothelium-derived contracting factor in carotid artery of hypertensive Dahl rats. Hypertension. 1999 Jul;34(1):39-43. PubMed PMID: 10406821.
6: Zhou MS, Kosaka H, Tian RX, Abe Y, Chen QH, Yoneyama H, Yamamoto A, Zhang L. L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats. J Hypertens. 2001 Mar;19(3):421-9. PubMed PMID: 11288812.
7: Kurosawa M, Yodonawa S, Inamura H, Tsukagoshi H. Inhibition by thromboxane antagonists of airway hyperresponsiveness to histamine induced by 13,14-dihydro-15-keto-PGF2 alpha in guinea-pigs. Clin Exp Allergy. 1994 Jul;24(7):669-75. PubMed PMID: 7953949.
8: Yodonawa S, Kurosawa M. [Bronchial hyperresponsiveness to histamine induced by intravenous administration of 13,14-dihydro-15-keto-prostaglandin F2 alpha in guinea pigs]. Nihon Yakurigaku Zasshi. 1994 Mar;103(3):91-9. Japanese. PubMed PMID: 8144105.
9: Kurosawa M, Yodonawa S, Tsukagoshi H. Inhibition of 9 alpha,11 beta-prostaglandin F2-induced bronchial hyperresponsiveness by thromboxane A2 receptor antagonists in guinea pigs. Eur J Pharmacol. 1993 Jul 20;238(2-3):335-41. PubMed PMID: 8405102.
10: Yodonawa S, Tsukagoshi H, Kurosawa M. [Effect of thromboxane A2 (TXA2) antagonists on bronchial hyperresponsiveness induced by intravenous administration of leukotriene C4 (LTC4) in guinea pigs]. Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Feb;31(2):162-8. Japanese. PubMed PMID: 8515595.
11: Tsukagoshi H, Kurosawa M. [Bronchial hyperresponsiveness to histamine induced by intravenous administration of prostaglandin D2 (PGD2) in guinea pigs]. Nihon Yakurigaku Zasshi. 1992 Feb;99(2):83-91. Japanese. PubMed PMID: 1559641.
12: Tsukagoshi H, Kurosawa M. [Bronchial hyperresponsiveness to histamine induced by intravenous administration of thromboxane A2 (TXA2) in guinea-pigs]. Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Dec;29(12):1532-7. Japanese. PubMed PMID: 1808375.
13: Tsukagoshi H, Yodonawa S, Kurosawa M. [Effect of thromboxane A2 synthetase inhibitor (OKY-046) on leukotriene C4-induced airway hyperresponsiveness in guinea pigs]. Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Jun;31(6):707-11. Japanese. PubMed PMID: 8345703.
14: Yodonawa S, Tsukagoshi H, Kurosawa M. [Bronchial hyperresponsiveness to histamine induced by intravenous administration of 9 alpha,11 beta-prostaglandin F2 (9 alpha,11 beta-PGF2) in guinea pigs]. Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Jan;31(1):12-9. Japanese. PubMed PMID: 8468814.
15: Iwama Y, Kato T, Muramatsu M, Asano H, Shimizu K, Toki Y, Miyazaki Y, Okumura K, Hashimoto H, Ito T, et al. Correlation with blood pressure of the acetylcholine-induced endothelium-derived contracting factor in the rat aorta. Hypertension. 1992 Apr;19(4):326-32. PubMed PMID: 1555864.
16: Nambu F, Yube N, Omawari N, Sawada M, Okegawa T, Kawasaki A, Ikeda S. Inhibition of endothelin-induced bronchoconstriction by OKY-046, a selective thromboxane A2 synthetase inhibitor, in guinea pigs. Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:453-6. PubMed PMID: 1825581.
