WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H531992
CAS#: 401907-26-4
Description: JYL1421 is a TRPV1 receptor antagonist.
Hodoodo Cat#: H531992
Name: JYL1421
CAS#: 401907-26-4
Chemical Formula: C20H26FN3O2S2
Exact Mass: 423.15
Molecular Weight: 423.570
Elemental Analysis: C, 56.71; H, 6.19; F, 4.49; N, 9.92; O, 7.55; S, 15.14
Synonym: JYL1421; JYL 1421; JYL-1421.
IUPAC/Chemical Name: 3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-methanesulfonamidophenyl)methyl]thiourea
InChi Key: DUHBVFMCIJLUJX-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
SMILES Code: S=C(NCC1=CC=C(C(C)(C)C)C=C1)NCC2=CC=C(NS(=O)(C)=O)C(F)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 423.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Jakab B, Helyes Z, Varga A, Bölcskei K, Szabó A, Sándor K, Elekes K, Börzsei R, Keszthelyi D, Pintér E, Petho G, Németh J, Szolcsányi J. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. Eur J Pharmacol. 2005 Jul 4;517(1-2):35-44. PubMed PMID: 15978575.