WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530520
CAS#: 1001015-18-4
Description: CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 is more effective than other CO-RMs under H2O2-induced oxidative stress conditions. CORM-401 released up to three CO/mole of compound depending on the concentration of the acceptor myoglobin. Oxidants such as H2O2, tert-butyl hydroperoxide or hypochlorous acid increased the CO liberated by CORM-401. CORM-401 also relaxed pre-contracted aortic rings and vasorelaxation was enhanced in combination with H2O2.
Hodoodo Cat#: H530520
Name: CORM-401
CAS#: 1001015-18-4
Chemical Formula: C8H6MnNO6S2
Exact Mass: 330.90
Molecular Weight: 331.195
Elemental Analysis: C, 29.01; H, 1.83; Mn, 16.59; N, 4.23; O, 28.98; S, 19.36
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Related CAS #: 1001040-67-0 (cation) 1001015-18-4
Synonym: CORM-401; CORM 401; CORM401.
IUPAC/Chemical Name: Manganate(1-), tetracarbonyl[N-(dithiocarboxy-κS,κS')-N-methylglycinato(2-)]-, hydrogen (1:1), (OC-6-22)-
InChi Key: PBEOVQBORDYRJY-UHFFFAOYSA-M
InChi Code: InChI=1S/C4H7NO2S2.4CO.Mn/c1-5(4(8)9)2-3(6)7;4*1-2;/h2H2,1H3,(H,6,7)(H,8,9);;;;;/q;4*+1;-3/p-1
SMILES Code: OC(CN(C)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Carbon monoxide (CO) is generated by heme oxygenase-1 (HO-1) and displays important signaling, anti-apoptotic and anti-inflammatory activities, indicating that pharmacological agents mimicking its action may have therapeutic benefit.
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The following data is based on the product molecular weight 331.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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1: Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chlopicki S. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels. Biochim Biophys Acta. 2015 Oct;1847(10):1297-309. doi: 10.1016/j.bbabio.2015.07.004. PubMed PMID: 26185029.
2: Babu D, Leclercq G, Motterlini R, Lefebvre RA. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Front Pharmacol. 2017 Feb 8;8:31. doi: 10.3389/fphar.2017.00031. PubMed PMID: 28228725; PubMed Central PMCID: PMC5296622.
3: Fayad-Kobeissi S, Ratovonantenaina J, Dabiré H, Wilson JL, Rodriguez AM, Berdeaux A, Dubois-Randé JL, Mann BE, Motterlini R, Foresti R. Vascular and angiogenic activities of CORM-401, an oxidant-sensitive CO-releasing molecule. Biochem Pharmacol. 2016 Feb 15;102:64-77. doi: 10.1016/j.bcp.2015.12.014. PubMed PMID: 26721585.
4: Kaczara P, Motterlini R, Kus K, Zakrzewska A, Abramov AY, Chlopicki S. Carbon monoxide shifts energetic metabolism from glycolysis to oxidative phosphorylation in endothelial cells. FEBS Lett. 2016 Oct;590(20):3469-3480. doi: 10.1002/1873-3468.12434. PubMed PMID: 27670394.
5: Wilson JL, Bouillaud F, Almeida AS, Vieira HL, Ouidja MO, Dubois-Randé JL, Foresti R, Motterlini R. Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus. Free Radic Biol Med. 2017 Mar;104:311-323. doi: 10.1016/j.freeradbiomed.2017.01.022. PubMed PMID: 28108277.
6: Vummaleti SV, Branduardi D, Masetti M, De Vivo M, Motterlini R, Cavalli A. Theoretical insights into the mechanism of carbon monoxide (CO) release from CO-releasing molecules. Chemistry. 2012 Jul 23;18(30):9267-75. doi: 10.1002/chem.201103617. PubMed PMID: 22730163.
