WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H329604
CAS#: 137-26-8
Description: Thiram is a fungicide, ectoparasiticide, and animal repellent. It is used to prevent fungal diseases in seed and crops. It is also used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents and deer. It is effective against Stem gall of coriander, damping off, smut of millet, neck rot of onion, etc. Thiram has been used in the treatment of human scabies, as a sun screen and as a bactericide applied directly to the skin or incorporated into soap.
Hodoodo Cat#: H329604
Name: Thiram
CAS#: 137-26-8
Chemical Formula: C6H12N2S4
Exact Mass: 239.99
Molecular Weight: 240.416
Elemental Analysis: C, 29.98; H, 5.03; N, 11.65; S, 53.34
Synonym: Thiram; Bis(dimethylthiocarbamoyl) disulfide, Bis(dimethylthiocarbamyl) disulfide,
IUPAC/Chemical Name: Tetramethylthiuram Disulfide
InChi Key: KUAZQDVKQLNFPE-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
SMILES Code: S=C(SSC(N(C)C)=S)N(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 240.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sharma VK, Aulakh JS, Malik AK. Thiram: degradation, applications and analytical methods. J Environ Monit. 2003 Oct;5(5):717-23. Review. PubMed PMID: 14587840.
2: Gallori E, Casalone E, Colella CM, Daly S, Polsinelli M. 1,8-Naphthalic anhydride antidote enhances the toxic effects of captan and thiram fungicides on Azospirillum brasilense cells. Res Microbiol. 1991 Nov-Dec;142(9):1005-12. Review. PubMed PMID: 1805302.
3: Thiram. IARC Monogr Eval Carcinog Risks Hum. 1991;53:403-22. Review. PubMed PMID: 1842585.
4: Dalvi RR. Toxicology of thiram (tetramethylthiuram disulfide): a review. Vet Hum Toxicol. 1988 Oct;30(5):480-2. Review. PubMed PMID: 3055654.
5: Wesley NO, Maibach HI. Decreasing allergic contact dermatitis frequency through dermatotoxicologic and epidemiologic based intervention? Food Chem Toxicol. 2003 Jun;41(6):857-60. Review. PubMed PMID: 12738190.
6: Fishbein L. Environmental health aspects of fungicides. I. Dithiocarbamtes. J Toxicol Environ Health. 1976 May;1(5):713-35. Review. PubMed PMID: 775114.
7: Marzulli FN, Maibach HI. Contact allergy: predictive testing in man. Contact Dermatitis. 1976 Feb;2(1):1-17. Review. PubMed PMID: 801606.
8: Dooms-Goossens AE, Debusschere KM, Gevers DM, Dupré KM, Degreef HJ, Loncke JP, Snauwaert JE. Contact dermatitis caused by airborne agents. A review and case reports. J Am Acad Dermatol. 1986 Jul;15(1):1-10. Review. PubMed PMID: 2941461.
9: Goicoechea N. To what extent are soil amendments useful to control Verticillium wilt? Pest Manag Sci. 2009 Aug;65(8):831-9. doi: 10.1002/ps.1774. Review. PubMed PMID: 19402078.
10: Pócsi I, Prade RA, Penninckx MJ. Glutathione, altruistic metabolite in fungi. Adv Microb Physiol. 2004;49:1-76. Review. PubMed PMID: 15518828.
11: Orth MW, Cook ME. Avian tibial dyschondroplasia: a morphological and biochemical review of the growth plate lesion and its causes. Vet Pathol. 1994 Jul;31(4):403-4. Review. PubMed PMID: 7941228.
12: Vettorazzi G, Almeida WF, Burin GJ, Jaeger RB, Puga FR, Rahde AF, Reyes FG, Schvartsman S. International safety assessment of pesticides: dithiocarbamate pesticides, ETU, and PTU--a review and update. Teratog Carcinog Mutagen. 1995-1996;15(6):313-37. Review. PubMed PMID: 8732882.
