WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532083
CAS#: 1021868-80-3
Description: L-750,667 TriHydrochloride is a selective D4 dopamine receptor antagonist.
Hodoodo Cat#: H532083
Name: L-750,667 TriHydrochloride
CAS#: 1021868-80-3
Chemical Formula: C18H22Cl3IN4
Exact Mass: 0.00
Molecular Weight: 527.657
Elemental Analysis: C, 40.97; H, 4.20; Cl, 20.16; I, 24.05; N, 10.62
Synonym: L-750,667; L 750,667; L750,667.
IUPAC/Chemical Name: 3-[4-(4-Iodophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
InChi Key: YOURSPNOEWYAKO-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H19IN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H
SMILES Code: IC1=CC=C(N2CCN(CC3=CNC4=NC=CC=C43)CC2)C=C1.[H]Cl.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 527.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
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In vivo protocol: |
1: Kawano M, Takagi R, Kaneko A, Matsushita S. Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses. J Neuroimmunol. 2015 Dec 15;289:43-55. doi: 10.1016/j.jneuroim.2015.10.001. PubMed PMID: 26616870.