HM-50316

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H530530

CAS#: 1310361-52-4

Description: HM-50316 is a High affinity FABP4 inhibitor (Ki < 1 nM). HM-50316 may serve as a lead compound for developing new effective therapeutic agent for prevention and treatment of atherosclerosis, type 2 diabetes and other inflammatory and metabolic related diseases. a-FABP is indespensible in inflammation and may serve as a new potential drug target for inflammation related diseases.


Chemical Structure

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HM-50316
CAS# 1310361-52-4

Theoretical Analysis

Hodoodo Cat#: H530530
Name: HM-50316
CAS#: 1310361-52-4
Chemical Formula: C29H23ClN2O3S
Exact Mass: 514.11
Molecular Weight: 515.024
Elemental Analysis: C, 67.63; H, 4.50; Cl, 6.88; N, 5.44; O, 9.32; S, 6.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: HM-50316; HM 50316; HM50316.

IUPAC/Chemical Name: 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid

InChi Key: HOACFVYJBHHSBC-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H23ClN2O3S/c1-29(2,28(33)34)35-22-8-5-7-19(17-22)23-9-3-4-10-24(23)25-18-26(27-11-6-16-36-27)32(31-25)21-14-12-20(30)13-15-21/h3-18H,1-2H3,(H,33,34)

SMILES Code: CC(C)(OC1=CC(C2=CC=CC=C2C3=NN(C4=CC=C(Cl)C=C4)C(C5=CC=CS5)=C3)=CC=C1)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 515.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D, Ke D.
New aromatic substituted pyrazoles as selective inhibitors of human adipocyte
fatty acid-binding protein. Bioorg Med Chem Lett. 2011 May 15;21(10):2949-52.
doi: 10.1016/j.bmcl.2011.03.063. PubMed PMID: 21481589.