WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530530
CAS#: 1310361-52-4
Description: HM-50316 is a High affinity FABP4 inhibitor (Ki < 1 nM). HM-50316 may serve as a lead compound for developing new effective therapeutic agent for prevention and treatment of atherosclerosis, type 2 diabetes and other inflammatory and metabolic related diseases. a-FABP is indespensible in inflammation and may serve as a new potential drug target for inflammation related diseases.
Hodoodo Cat#: H530530
Name: HM-50316
CAS#: 1310361-52-4
Chemical Formula: C29H23ClN2O3S
Exact Mass: 514.11
Molecular Weight: 515.024
Elemental Analysis: C, 67.63; H, 4.50; Cl, 6.88; N, 5.44; O, 9.32; S, 6.22
This product is not in stock, which may be available by custom synthesis.
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Synonym: HM-50316; HM 50316; HM50316.
IUPAC/Chemical Name: 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid
InChi Key: HOACFVYJBHHSBC-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H23ClN2O3S/c1-29(2,28(33)34)35-22-8-5-7-19(17-22)23-9-3-4-10-24(23)25-18-26(27-11-6-16-36-27)32(31-25)21-14-12-20(30)13-15-21/h3-18H,1-2H3,(H,33,34)
SMILES Code: CC(C)(OC1=CC(C2=CC=CC=C2C3=NN(C4=CC=C(Cl)C=C4)C(C5=CC=CS5)=C3)=CC=C1)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 515.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D, Ke D.
New aromatic substituted pyrazoles as selective inhibitors of human adipocyte
fatty acid-binding protein. Bioorg Med Chem Lett. 2011 May 15;21(10):2949-52.
doi: 10.1016/j.bmcl.2011.03.063. PubMed PMID: 21481589.