WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529010
CAS#: 805241-79-6
Description: PPD 10558, also known as RBx 10558, is a HMG-CoA reductase inhibitor potentially for treatment of primary hypercholesterolemia.
Hodoodo Cat#: H529010
Name: PPD 10558
CAS#: 805241-79-6
Chemical Formula: C34H37FN2O6
Exact Mass: 588.26
Molecular Weight: 588.676
Elemental Analysis: C, 69.37; H, 6.34; F, 3.23; N, 4.76; O, 16.31
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Synonym: PPD-10558; RBx-10558; PPD10558; RBx10558; PPD 10558; RBx 10558, bemfivastatin
IUPAC/Chemical Name: 7-(2-(4-fluorophenyl)-4-((4-(hydroxymethyl)phenyl)carbamoyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
InChi Key: PMFRPLBQEYHUMG-UHFFFAOYSA-N
InChi Code: InChI=1S/C34H37FN2O6/c1-21(2)32-31(34(43)36-26-14-8-22(20-38)9-15-26)30(23-6-4-3-5-7-23)33(24-10-12-25(35)13-11-24)37(32)17-16-27(39)18-28(40)19-29(41)42/h3-15,21,27-28,38-40H,16-20H2,1-2H3,(H,36,43)(H,41,42)
SMILES Code: O=C(O)CC(O)CC(O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC=C3)C(C(NC4=CC=C(CO)C=C4)=O)=C1C(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 588.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Faqi AS, Prohaska D, Lopez R, McIntyre G. Developmental toxicity of the
HMG-CoA reductase inhibitor (PPD10558) in rats and rabbits. Birth Defects Res B
Dev Reprod Toxicol. 2012 Feb;95(1):23-37. doi: 10.1002/bdrb.20337. PubMed PMID:
22006546.