WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529011
CAS#: 341524-89-8
Description: Fispemifene, also known as HM-101, is a selective estrogen receptor modulator (SERM) potentially for the treatment of hypogonadism.
Hodoodo Cat#: H529011
Name: Fispemifene
CAS#: 341524-89-8
Chemical Formula: C26H27ClO3
Exact Mass: 422.16
Molecular Weight: 422.940
Elemental Analysis: C, 73.84; H, 6.43; Cl, 8.38; O, 11.35
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Synonym: HM-101; HM101; HM 101
IUPAC/Chemical Name: (Z)-2-(2-(4-(4-chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethoxy)ethan-1-ol
InChi Key: NKZTZAQIKKGTDB-QPLCGJKRSA-N
InChi Code: InChI=1S/C26H27ClO3/c27-16-15-25(21-7-3-1-4-8-21)26(22-9-5-2-6-10-22)23-11-13-24(14-12-23)30-20-19-29-18-17-28/h1-14,28H,15-20H2/b26-25-
SMILES Code: ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCOCCO)C=C2)\C3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 422.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yatkin E, Bernoulli J, Lammintausta R, Santti R. Fispemifene [Z-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}-ethanol], a novel selective estrogen receptor modulator, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis. J Pharmacol Exp Ther. 2008 Oct;327(1):58-67. doi: 10.1124/jpet.108.139501. PubMed PMID: 18583549.
2: Savolainen-Peltonen H, Luoto NM, Kangas L, Häyry P. Selective estrogen receptor modulators prevent neointima formation after vascular injury. Mol Cell Endocrinol. 2004 Nov 30;227(1-2):9-20. PubMed PMID: 15501580.