ITH-12575

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H530536

CAS#: 1802013-08-6

Description: ITH-12575 is a Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. ITH12575 reduced Ca(2+) influx through CALHM1 at low micromolar concentrations.


Chemical Structure

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ITH-12575
CAS# 1802013-08-6

Theoretical Analysis

Hodoodo Cat#: H530536
Name: ITH-12575
CAS#: 1802013-08-6
Chemical Formula: C18H18ClNOS
Exact Mass: 331.08
Molecular Weight: 331.858
Elemental Analysis: C, 65.15; H, 5.47; Cl, 10.68; N, 4.22; O, 4.82; S, 9.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ITH-12575; ITH 12575; ITH12575.

IUPAC/Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one

InChi Key: RDMUJSJZBYAAEF-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18ClNOS/c1-11(2)13-5-3-4-6-14(13)18-15-9-12(19)7-8-16(15)20-17(21)10-22-18/h3-9,11,18H,10H2,1-2H3,(H,20,21)

SMILES Code: O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3C(C)C)SC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Moreno-Ortega AJ, Martínez-Sanz FJ, Lajarín-Cuesta R, de Los Rios C, Cano-Abad
MF. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry
through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. doi:
10.1016/j.neuropharm.2015.02.016. PubMed PMID: 25908402.


2: Martínez-Sanz FJ, Lajarín-Cuesta R, González-Lafuente L, Moreno-Ortega AJ,
Punzón E, Cano-Abad MF, de los Ríos C. Neuroprotective profile of
pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+)
exchanger. Eur J Med Chem. 2016 Feb 15;109:114-23. doi:
10.1016/j.ejmech.2015.12.043. PubMed PMID: 26774037.


3: Martínez-Sanz FJ, Lajarín-Cuesta R, Moreno-Ortega AJ, González-Lafuente L,
Fernández-Morales JC, López-Arribas R, Cano-Abad MF, de los Ríos C.
Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro
Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. doi:
10.1021/acschemneuro.5b00161. PubMed PMID: 26192029.