WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530536
CAS#: 1802013-08-6
Description: ITH-12575 is a Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. ITH12575 reduced Ca(2+) influx through CALHM1 at low micromolar concentrations.
Hodoodo Cat#: H530536
Name: ITH-12575
CAS#: 1802013-08-6
Chemical Formula: C18H18ClNOS
Exact Mass: 331.08
Molecular Weight: 331.858
Elemental Analysis: C, 65.15; H, 5.47; Cl, 10.68; N, 4.22; O, 4.82; S, 9.66
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Synonym: ITH-12575; ITH 12575; ITH12575.
IUPAC/Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
InChi Key: RDMUJSJZBYAAEF-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H18ClNOS/c1-11(2)13-5-3-4-6-14(13)18-15-9-12(19)7-8-16(15)20-17(21)10-22-18/h3-9,11,18H,10H2,1-2H3,(H,20,21)
SMILES Code: O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3C(C)C)SC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 331.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Moreno-Ortega AJ, Martínez-Sanz FJ, Lajarín-Cuesta R, de Los Rios C, Cano-Abad
MF. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry
through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. doi:
10.1016/j.neuropharm.2015.02.016. PubMed PMID: 25908402.
2: Martínez-Sanz FJ, Lajarín-Cuesta R, González-Lafuente L, Moreno-Ortega AJ,
Punzón E, Cano-Abad MF, de los Ríos C. Neuroprotective profile of
pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+)
exchanger. Eur J Med Chem. 2016 Feb 15;109:114-23. doi:
10.1016/j.ejmech.2015.12.043. PubMed PMID: 26774037.
3: Martínez-Sanz FJ, Lajarín-Cuesta R, Moreno-Ortega AJ, González-Lafuente L,
Fernández-Morales JC, López-Arribas R, Cano-Abad MF, de los Ríos C.
Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro
Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. doi:
10.1021/acschemneuro.5b00161. PubMed PMID: 26192029.