WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532164
CAS#: 191471-52-0
Description: LY-379,268 is a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3). LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals, and blocks the effects of PCP and DOI, which has led to research as antipsychotic drugs for the treatment of schizophrenia in animals.
Hodoodo Cat#: H532164
Name: LY379268
CAS#: 191471-52-0
Chemical Formula: C7H9NO5
Exact Mass: 187.05
Molecular Weight: 187.151
Elemental Analysis: C, 44.92; H, 4.85; N, 7.48; O, 42.74
Synonym: LY379268; LY 379268; LY-379268.
IUPAC/Chemical Name: (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid
InChi Key: YASVRZWVUGJELU-MDASVERJSA-N
InChi Code: InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
SMILES Code: O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])OC1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 187.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug Alcohol Depend. 2016 Sep 1;166:51-60. doi: 10.1016/j.drugalcdep.2016.06.020. PubMed PMID: 27394931; PubMed Central PMCID: PMC5003316.
2: Engel M, Snikeris P, Matosin N, Newell KA, Huang XF, Frank E. Erratum to: mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia. Psychopharmacology (Berl). 2016 Apr;233(8):1537. doi: 10.1007/s00213-016-4261-6. PubMed PMID: 26955838.
3: Engel M, Snikeris P, Matosin N, Newell KA, Huang XF, Frank E. mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia. Psychopharmacology (Berl). 2016 Apr;233(8):1349-59. doi: 10.1007/s00213-016-4230-0. Erratum in: Psychopharmacology (Berl). 2016 Apr;233(8):1537. PubMed PMID: 26861891.
4: Myal S, O'Donnell P, Counotte DS. Nucleus accumbens injections of the mGluR2/3 agonist LY379268 increase cue-induced sucrose seeking following adult, but not adolescent sucrose self-administration. Neuroscience. 2015 Oct 1;305:309-15. doi: 10.1016/j.neuroscience.2015.07.077. PubMed PMID: 26241341; PubMed Central PMCID: PMC4559755.
5: Justinova Z, Le Foll B, Redhi GH, Markou A, Goldberg SR. Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. Psychopharmacology (Berl). 2016 May;233(10):1791-800. doi: 10.1007/s00213-015-3994-y. PubMed PMID: 26149611; PubMed Central PMCID: PMC4706511.
