WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532181
CAS#: 321963-33-1
Description: MGS0028 is a selective metabotropic glutamate 2/3 receptor agonist. MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.
Hodoodo Cat#: H532181
Name: MGS0028
CAS#: 321963-33-1
Chemical Formula: C8H8FNO5
Exact Mass: 217.04
Molecular Weight: 217.150
Elemental Analysis: C, 44.25; H, 3.71; F, 8.75; N, 6.45; O, 36.84
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: MGS0028; MGS 0028; MGS-0028.
IUPAC/Chemical Name: (1R,2S,5S,6S)-2-amino-6-fluoro-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
InChi Key: KFAGJPNFERWZJA-JKBXLQNXSA-N
InChi Code: InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
SMILES Code: O=C([C@@](C1)(N)[C@]2([H])[C@](C(O)=O)(F)[C@]2([H])C1=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 217.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ago Y, Hiramatsu N, Ishihama T, Hazama K, Hayata-Takano A, Shibasaki Y, Shintani N, Hashimoto H, Kawasaki T, Onoe H, Chaki S, Nakazato A, Baba A, Takuma K, Matsuda T. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide. Behav Pharmacol. 2013 Feb;24(1):74-7. doi: 10.1097/FBP.0b013e32835cf3e5. PubMed PMID: 23268987.
2: Ago Y, Araki R, Yano K, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice. J Pharmacol Sci. 2012;118(2):295-8. PubMed PMID: 22293290.
3: Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T. Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. Psychopharmacology (Berl). 2011 Oct;217(3):443-52. doi: 10.1007/s00213-011-2295-3. PubMed PMID: 21487651.
4: James JK, Nakamura M, Nakazato A, Zhang KE, Cramer M, Brunner J, Cook J, Chen WG. Metabolism and disposition of a potent group II metabotropic glutamate receptor agonist, in rats, dogs, and monkeys. Drug Metab Dispos. 2005 Sep;33(9):1373-81. PubMed PMID: 15980102.
5: Zhang F, Song ZJ, Tschaen D, Volante RP. Enantioselective preparation of ring-fused 1-fluorocyclopropane-1-carboxylate derivatives: en route to mGluR 2 receptor agonist MGS0028. Org Lett. 2004 Oct 14;6(21):3775-7. PubMed PMID: 15469346.
6: Robins P. Japanese Pharmacological Society--77th Annual Meeting. Part I. 8-10 March 2004, Osaka, Japan. IDrugs. 2004 Apr;7(4):295-7. PubMed PMID: 15057628.
7: Takamori K, Hirota S, Chaki S, Tanaka M. Antipsychotic action of selective group II metabotropic glutamate receptor agonist MGS0008 and MGS0028 on conditioned avoidance responses in the rat. Life Sci. 2003 Aug 15;73(13):1721-8. PubMed PMID: 12875903.
8: Nakazato A, Kumagai T, Sakagami K, Yoshikawa R, Suzuki Y, Chaki S, Ito H, Taguchi T, Nakanishi S, Okuyama S. Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. J Med Chem. 2000 Dec 14;43(25):4893-909. PubMed PMID: 11123999.
