Norathiol

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H528808

CAS#: 94161-07-6 (Na)

Description: Norathiol, also called NOX-100, is a nitric oxide (NO) scavenger potentially for the prevention of hypotension during hemodialysis and septic shock.

Chemical Structure

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Norathiol
CAS# 94161-07-6 (Na)
Instruction

Theoretical Analysis

Hodoodo Cat#: H528808
Name: Norathiol
CAS#: 94161-07-6 (Na)
Chemical Formula: C8H16NNaO5S2
Exact Mass: 293.04
Molecular Weight: 293.320
Elemental Analysis: C, 32.76; H, 5.50; N, 4.78; Na, 7.84; O, 27.27; S, 21.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 91840-27-6  

Synonym: NOX-100; NOX100; NOX 100

IUPAC/Chemical Name: sodium methyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)carbamodithioate

InChi Key: PLQRBFAACWRSKF-LJTMIZJLSA-M

InChi Code: InChI=1S/C8H17NO5S2.Na/c1-9(8(15)16)2-4(11)6(13)7(14)5(12)3-10;/h4-7,10-14H,2-3H2,1H3,(H,15,16);/q;+1/p-1/t4-,5+,6+,7+;/m0./s1

SMILES Code: O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CN(C([S-])=S)C.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 293.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sato M, Ohtsuka T, Stell WK. Endogenous nitric oxide enhances the light-response of cones during light-adaptation in the rat retina. Vision Res. 2011 Jan;51(1):131-7. doi: 10.1016/j.visres.2010.10.011. PubMed PMID: 20951158.

2: Mihailovic-Stanojevic N, Belščak-Cvitanović A, Grujić-Milanović J, Ivanov M, Jovović Dj, Bugarski D, Miloradović Z. Antioxidant and antihypertensive activity of extract from Thymus serpyllum L. in experimental hypertension. Plant Foods Hum Nutr. 2013 Sep;68(3):235-40. doi: 10.1007/s11130-013-0368-7. PubMed PMID: 23828496.

3: Nadler EP, Dickinson EC, Beer-Stolz D, Alber SM, Watkins SC, Pratt DW, Ford HR. Scavenging nitric oxide reduces hepatocellular injury after endotoxin challenge. Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G173-81. PubMed PMID: 11408270.

4: Roza AM, Cooper M, Pieper G, Hilton G, Dembny K, Lai CS, Lindholm P, Komorowski R, Felix C, Johnson C, Adams M. NOX 100, a nitric oxide scavenger, enhances cardiac allograft survival and promotes long-term graft acceptance. Transplantation. 2000 Jan 27;69(2):227-31. PubMed PMID: 10670631.

5: Hierholzer C, Billiar TR, Tweardy DJ, Harbrecht B. Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging. Arch Orthop Trauma Surg. 2003 Apr;123(2-3):55-9. PubMed PMID: 12721681.

6: Kagota S, Yamaguchi Y, Nakamura K, Shinozuka K, Kunitomo M. Chronic nitric oxide exposure alters the balance between endothelium-derived relaxing factors released from rat renal arteries: prevention by treatment with NOX-100, a NO scavenger. Life Sci. 2004 Apr 16;74(22):2757-67. PubMed PMID: 15043990.