Clidanac

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Hodoodo CAT#: H329615

CAS#: 34148-01-1

Description: Clidanac, also known as TAI-284, is a potent anti-inflammatory drug. Clidanac was found to uncouple the oxidative phosphorylation and no difference was detected in the uncoupling potency of the two enantiomorphs.


Chemical Structure

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Clidanac
CAS# 34148-01-1

Theoretical Analysis

Hodoodo Cat#: H329615
Name: Clidanac
CAS#: 34148-01-1
Chemical Formula: C16H19ClO2
Exact Mass: 278.11
Molecular Weight: 278.776
Elemental Analysis: C, 68.94; H, 6.87; Cl, 12.72; O, 11.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 28998-45-0   28968-09-4   34148-01-1    

Synonym: Clidanac; Britai; Clidanaco; TAI-284; TAI 284; TAI284; dl-TAI 284; Indanal.

IUPAC/Chemical Name: 6-Chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid

InChi Key: OIRAEJWYWSAQNG-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19ClO2/c17-15-9-13-11(6-7-12(13)16(18)19)8-14(15)10-4-2-1-3-5-10/h8-10,12H,1-7H2,(H,18,19)

SMILES Code: O=C(C1CCC2=C1C=C(Cl)C(C3CCCCC3)=C2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 278.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kawai K, Shiojiri H, Fukushima H, Nozawa Y, Hasegawa J, Nozaki M, Tsurumi K, Fujimura H. The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers. Res Commun Chem Pathol Pharmacol. 1984 Sep;45(3):399-406. PubMed PMID: 6334337.

2: Boettcher I, Elger W, Kirsch G, Siegmund F, Wachtel H. Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid. J Med Chem. 1984 Mar;27(3):413-4. PubMed PMID: 6608000.

3: Hasegawa J, Nozaki M, Fujimura H. [The effects of various drugs on the binding site of bilirubin in serum albumin]. Nihon Yakurigaku Zasshi. 1984 Jan;83(1):79-83. Japanese. PubMed PMID: 6714852.

4: Hutt AJ, Caldwell J. The metabolic chiral inversion of 2-arylpropionic acids--a novel route with pharmacological consequences. J Pharm Pharmacol. 1983 Nov;35(11):693-704. Review. PubMed PMID: 6139449.

5: Imai H, Niwa M, Nozaki M, Tsurumi K, Fujimura H. [Influence of indomethacin and clidanac on the blood pressure lowering effect of beta-blockers]. Nihon Yakurigaku Zasshi. 1983 Jan;81(1):13-20. Japanese. PubMed PMID: 6133820.

6: Tamura S, Kuzuna S, Kawai K, Kishimoto S. Optical isomerization of R(-)-clidanac to the biologically active S(+)-isomer in guinea-pigs. J Pharm Pharmacol. 1981 Nov;33(11):701-6. PubMed PMID: 6118407.

7: Tamura S, Kuzuna S, Kawai K. Inhibition of prostaglandin biosynthesis by clidanac and related compounds: structural and conformational requirements for PG synthetase inhibition. J Pharm Pharmacol. 1981 Jan;33(1):29-32. PubMed PMID: 6114148.

8: Rosazza JP, Smith RV. Microbial models for drug metabolism. Adv Appl Microbiol. 1979;25:169-208. Review. PubMed PMID: 397736.