WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H528601
CAS#: 895169-20-7
Description: ONO-2952 is a peripheral benzodiazepine receptor antagonist potentially for the treatment of irritable bowel syndrome.
Hodoodo Cat#: H528601
Name: ONO-2952
CAS#: 895169-20-7
Chemical Formula: C22H20ClFN2O2
Exact Mass: 398.12
Molecular Weight: 398.860
Elemental Analysis: C, 66.25; H, 5.05; Cl, 8.89; F, 4.76; N, 7.02; O, 8.02
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Synonym: ONO-2952; ONO2952; ONO 2952
IUPAC/Chemical Name: (S)-1-(1'-(4-chloro-2-methoxyphenyl)-5'-fluoro-1',9'-dihydrospiro[cyclopropane-1,4'-pyrido[3,4-b]indol]-2'(3'H)-yl)ethan-1-one
InChi Key: ZBQMTQGDBFZUBG-NRFANRHFSA-N
InChi Code: CC(N(C[15:S=N]HC[19]()=CC=C(Cl)C=C@19OC)CC[2](C[7]()=C(@15)NC[14]=C@8C(F)=CC=C@14)CC@3)=O
SMILES Code: CC(N([C@H]1C2=CC=C(Cl)C=C2OC)CC3(C4=C1NC5=C4C(F)=CC=C5)CC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 398.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Frankle WG, Narendran R, Wood AT, Suto F, Himes ML, Kobayashi M, Ohno T, Yamauchi A, Mitsui K, Duffy K, Bruce M. Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [(11) C]PBR28. Synapse. 2017 Feb 28. doi: 10.1002/syn.21970. [Epub ahead of print] PubMed PMID: 28245513.
2: Mitsui K, Niwa T, Kawahara Y, Morimoto N, Ohmoto K, Kato M, Yamaura Y, Yoshimoto N, Suna H, Katsumata S. Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Neuropharmacology. 2015 Dec;99:51-66. doi: 10.1016/j.neuropharm.2015.07.011. Epub 2015 Jul 17. PubMed PMID: 26189762.
3: Suto F, Wood AT, Kobayashi M, Komaba J, Duffy K, Bruce M. Safety, Tolerability, and Pharmacokinetic Profile of the Novel Translocator Protein 18 kDa Antagonist ONO-2952 in Healthy Volunteers. Clin Ther. 2015 Sep;37(9):2071-84. doi: 10.1016/j.clinthera.2015.07.010. Epub 2015 Aug 4. PubMed PMID: 26249232.
4: Mitsui K, Morimoto N, Niwa T, Yamaura Y, Ohba H, Tsukada H, Katsumata S. Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography. J Pharmacol Exp Ther. 2017 Mar;360(3):457-465. doi: 10.1124/jpet.116.238568. Epub 2016 Dec 16. PubMed PMID: 27986860.
5: Whitehead WE, Duffy K, Sharpe J, Nabata T, Bruce M. Randomised clinical trial: exploratory phase 2 study of ONO-2952 in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2017 Jan;45(1):14-26. doi: 10.1111/apt.13839. Epub 2016 Nov 7. PubMed PMID: 27910150.
6: Nee J, Lembo A. Editorial: ONO-2952 in irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther. 2017 Apr;45(7):1004-1005. doi: 10.1111/apt.13920. PubMed PMID: 28256084.
7: Whitehead WE, Duffy K, Sharpe J, Nabata T, Bruce M. Editorial: ONO-2952 in irritable bowel syndrome with diarrhoea - authors' reply. Aliment Pharmacol Ther. 2017 Apr;45(7):1005. doi: 10.1111/apt.13957. PubMed PMID: 28256085.