WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407441
CAS#: 1083162-61-1
Description: FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS).
Hodoodo Cat#: H407441
Name: FIN56
CAS#: 1083162-61-1
Chemical Formula: C25H31N3O5S2
Exact Mass: 517.17
Molecular Weight: 517.659
Elemental Analysis: C, 58.01; H, 6.04; N, 8.12; O, 15.45; S, 12.39
Synonym: FIN56; FIN-56; FIN 56.
IUPAC/Chemical Name: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
InChi Key: JLCFMMIWBSZOIS-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2
SMILES Code: O=S(C1=CC(/C2=N\O)=C(C3=C2C=C(S(=O)(NC4CCCCC4)=O)C=C3)C=C1)(NC5CCCCC5)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 517.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM,
Valenzuela CA, Wolpaw AJ, Stockwell BR. Global survey of cell death mechanisms
reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016
Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9. PubMed PMID:
27159577; PubMed Central PMCID: PMC4920070.
2: Kolasa A. [Epididymis in an experimental model of DHT deficiency:
immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In
vivo and in vitro studies]. Ann Acad Med Stetin. 2006;52(2):13-21; discussion 21.
Polish. PubMed PMID: 17633123.