NIH-12848
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Hodoodo CAT#: H530601

CAS#: 959551-10-1

Description: NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor. NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1 μM but did not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

Chemical Structure

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NIH-12848
CAS# 959551-10-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H530601
Name: NIH-12848
CAS#: 959551-10-1
Chemical Formula: C20H14F3N3S
Exact Mass: 385.09
Molecular Weight: 385.408
Elemental Analysis: C, 62.33; H, 3.66; F, 14.79; N, 10.90; S, 8.32

Price and Availability

Size Price Availability Quantity
100mg USD 850 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2150 2 Weeks
1g USD 3450 2 Weeks
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Synonym: NIH-12848; NIH 12848; NIH12848, NCGC00012848-02.

IUPAC/Chemical Name: N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine

InChi Key: QBDAEJRHUCSSPR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26)

SMILES Code: FC(F)(F)C(C=CC=C1)=C1C2=NC3=CC=CC=C3C(NCC4=CC=CS4)=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Clarke JH, Giudici ML, Burke JE, Williams RL, Maloney DJ, Marugan J, Irvine
RF. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ)
explored using a specific inhibitor that targets the PI5P-binding site. Biochem
J. 2015 Mar 1;466(2):359-67. doi: 10.1042/BJ20141333. PubMed PMID: 25495341;
PubMed Central PMCID: PMC4687057.