ML311
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Hodoodo CAT#: H407459

CAS#: 315698-17-0

Description: ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. ML311 Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 will be a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.

Chemical Structure

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ML311
CAS# 315698-17-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H407459
Name: ML311
CAS#: 315698-17-0
Chemical Formula: C23H24F3N3O
Exact Mass: 415.19
Molecular Weight: 415.460
Elemental Analysis: C, 66.49; H, 5.82; F, 13.72; N, 10.11; O, 3.85

Price and Availability

Size Price Availability Quantity
100mg USD 1150 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 2450 2 Weeks
1g USD 3250 2 Weeks
2g USD 4950 2 Weeks
5g USD 6450 2 Weeks
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Synonym: ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346.

IUPAC/Chemical Name: 7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol

InChi Key: NGAPBLRRJSKIRT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3

SMILES Code: OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 415.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bannister T, Koenig M, He Y, Mishra J, Spicer T, Minond D, Saldanha A, Mercer
BA, Cameron M, Lena R, Carlson N, Richard D, Cardone M, Hodder P. ML311: A Small
Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction
of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. 2012 Apr 16
[updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program
[Internet]. Bethesda (MD): National Center for Biotechnology Information (US);
2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143557/
PubMed PMID: 23762927.