WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532488
CAS#: 409345-76-2
Description: R214127 is a novel high-affinity radioligand for the mGlu1 receptor.
Hodoodo Cat#: H532488
Name: R214127
CAS#: 409345-76-2
Chemical Formula: C20H17NO2
Exact Mass: 303.13
Molecular Weight: 303.360
Elemental Analysis: C, 79.19; H, 5.65; N, 4.62; O, 10.55
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Synonym: R214127; R 214127; R-214127.
IUPAC/Chemical Name: 1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenylethanone
InChi Key: HXUSRWUBSYSWII-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)15-8-9-18-17(12-15)13-16-7-4-10-23-20(16)21-18/h1-3,5-6,8-9,12-13H,4,7,10-11H2
SMILES Code: O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)CC4=CC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 303.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Simon L, Toth J, Molnar L, Agoston DV. MRI analysis of mGluR5 and mGluR1 antagonists, MTEP and R214127 in the cerebral forebrain of awake, conscious rats. Neurosci Lett. 2011 Nov 14;505(2):155-9. doi: 10.1016/j.neulet.2011.10.010. Epub 2011 Oct 12. PubMed PMID: 22015763.
2: Lavreysen H, Pereira SN, Leysen JE, Langlois X, Lesage AS. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr;46(5):609-19. PubMed PMID: 14996538.
3: Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. PubMed PMID: 12695537.