WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532617
CAS#: 296280-56-3
Description: S26131 is a bioactive chemical.
Hodoodo Cat#: H532617
Name: S26131
CAS#: 296280-56-3
Chemical Formula: C31H34N2O4
Exact Mass: 498.25
Molecular Weight: 498.620
Elemental Analysis: C, 74.67; H, 6.87; N, 5.62; O, 12.83
Synonym: S26131; S 26131; S-26131.
IUPAC/Chemical Name: N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide
InChi Key: NSXBZYDTTKLTOH-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H34N2O4/c1-22(34)32-16-14-26-8-3-6-24-10-12-28(20-30(24)26)36-18-5-19-37-29-13-11-25-7-4-9-27(31(25)21-29)15-17-33-23(2)35/h3-4,6-13,20-21H,5,14-19H2,1-2H3,(H,32,34)(H,33,35)
SMILES Code: CC(NCCC1=C2C=C(OCCCOC3=CC=C4C=CC=C(CCNC(C)=O)C4=C3)C=CC2=CC=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.0 | 10.03 |
The following data is based on the product molecular weight 498.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
Huang CT, Chen SH, Chang CF, Lin SC, Lue JH, Tsai YJ. Melatonin Reduces Neuropathic Pain Behavior and Glial Activation through MT2 Melatonin Receptor Modulation in a Rat Model of Lysophosphatidylcholine-Induced Demyelination Neuropathy [published online ahead of print, 2020 Aug 24]. Neurochem Int. 2020;104827. doi:10.1016/j.neuint.2020.104827
