BTdCPU
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Hodoodo CAT#: H407483

CAS#: 1257423-87-2

Description: BTdCPU is an activator of HRI. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Combination therapy with rapamycin, an mTOR inhibitor, and BTdCPU, an activator of HRI, demonstrated additive effects on apoptosis in dex-resistant cells. Thus, specific activation of the eIF2α kinase HRI is a novel therapeutic target in MM that can augment current treatment strategies.


Chemical Structure

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BTdCPU
CAS# 1257423-87-2

Theoretical Analysis

Hodoodo Cat#: H407483
Name: BTdCPU
CAS#: 1257423-87-2
Chemical Formula: C13H8Cl2N4OS
Exact Mass: 337.98
Molecular Weight: 339.194
Elemental Analysis: C, 46.03; H, 2.38; Cl, 20.90; N, 16.52; O, 4.72; S, 9.45

Price and Availability

Size Price Availability Quantity
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
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Synonym: BTdCPU

IUPAC/Chemical Name: 1-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea

InChi Key: NUUSUAWULNXMGF-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H8Cl2N4OS/c14-9-3-1-7(5-10(9)15)16-13(20)17-8-2-4-11-12(6-8)21-19-18-11/h1-6H,(H2,16,17,20)

SMILES Code: O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C3N=NSC3=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 339.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M,
Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A. The eIF2-alpha
kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017
Apr;55:23-32. doi: 10.1016/j.leukres.2017.01.007. Epub 2017 Jan 12. PubMed PMID:
28119225; PubMed Central PMCID: PMC5354961.