SM19712 free acid
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Hodoodo CAT#: H532753

CAS#: 194542-49-9 (free)

Description: SM19712 is a nonpeptide endothelin converting enzyme inhibitor.

Chemical Structure

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SM19712 free acid
CAS# 194542-49-9 (free)
Instruction

Theoretical Analysis

Hodoodo Cat#: H532753
Name: SM19712 free acid
CAS#: 194542-49-9 (free)
Chemical Formula: C18H14ClN5O3S
Exact Mass: 415.05
Molecular Weight: 415.852
Elemental Analysis: C, 51.99; H, 3.39; Cl, 8.52; N, 16.84; O, 11.54; S, 7.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 194542-49-9 (free)   194542-56-8 (sodium),  

Synonym: SM19712; SM-19712; SM 19712.

IUPAC/Chemical Name: 4-chloro-N-((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)carbamoyl)benzenesulfonamide

InChi Key: CWLFPWRNPQXWLD-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14ClN5O3S/c1-12-16(11-20)17(24(22-12)14-5-3-2-4-6-14)21-18(25)23-28(26,27)15-9-7-13(19)8-10-15/h2-10H,1H3,(H2,21,23,25)

SMILES Code: O=S(C1=CC=C(Cl)C=C1)(NC(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 415.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hasdemir B, Mahajan S, Bunnett NW, Liao M, Bhargava A. Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. Mol Endocrinol. 2012 Apr;26(4):681-95. doi: 10.1210/me.2011-1361. Epub 2012 Feb 9. PubMed PMID: 22322595; PubMed Central PMCID: PMC3327357.

2: Pelayo JC, Poole DP, Steinhoff M, Cottrell GS, Bunnett NW. Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. J Physiol. 2011 Nov 1;589(Pt 21):5213-30. doi: 10.1113/jphysiol.2011.214452. Epub 2011 Aug 30. PubMed PMID: 21878523; PubMed Central PMCID: PMC3225675.