WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H540043
CAS#: 65391-42-6 (HCl)
Description: Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.
Hodoodo Cat#: H540043
Name: Ubenimex HCl
CAS#: 65391-42-6 (HCl)
Chemical Formula: C16H25ClN2O4
Exact Mass: 344.15
Molecular Weight: 344.830
Elemental Analysis: C, 55.73; H, 7.31; Cl, 10.28; N, 8.12; O, 18.56
Related CAS #: 58970-76-6 (free base) 65391-42-6 (HCl)
Synonym: Bestatin HCl; Ubenimex, NK 421, NK-421, NK421, Bestatin, NSC 265489, NSC265489, NSC-265489
IUPAC/Chemical Name: ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine hydrochloride
InChi Key: XGDFITZJGKUSDK-UDYGKFQRSA-N
InChi Code: InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILES Code: CC(C)C[C@H](NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O)C(O)=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 344.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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2: Lwalaba D, Weidlich S, Hoffmann KH, Woodring J. Exogenous and endogenous protease inhibitors in the gut of the fall armyworm larvae, Spodoptera frugiperda. Arch Insect Biochem Physiol. 2010 Jun;74(2):114-26. doi: 10.1002/arch.20366. PubMed PMID: 20513059.
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4: Machida M, Hayashi M, Awazu S. The effects of absorption enhancers on the pulmonary absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. Biol Pharm Bull. 2000 Jan;23(1):84-6. PubMed PMID: 10706417.
5: Gee NS, Kenny AJ. Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W. Biochem J. 1987 Aug 15;246(1):97-102. PubMed PMID: 2890346; PubMed Central PMCID: PMC1148244.