WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525294
CAS#: 1642187-96-9
Description: TASP0390325 is a potent and orally active V1B receptor antagonist with antidepressant and anxiolytic activities in rodents.
Hodoodo Cat#: H525294
Name: TASP0390325
CAS#: 1642187-96-9
Chemical Formula: C25H30Cl2FN5O
Exact Mass: 553.17
Molecular Weight: 554.444
Elemental Analysis: C, 54.16; H, 5.45; Cl, 12.79; F, 3.43; N, 12.63; O, 11.54
Synonym: TASP0390325, TASP 0390325, TASP-0390325
IUPAC/Chemical Name: 2-[2-(3-Chloro-4-fluorophenyl)-6-[3-(morpholin-4-yl)propoxy]-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl]-N-isopropylacetamide hydrochloride
InChi Key: NUIXGNLBPARAII-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H29ClFN5O4.ClH/c1-16(2)29-22(33)15-32-24(17-4-5-21(27)20(26)12-17)30-23-19(25(32)34)13-18(14-28-23)36-9-3-6-31-7-10-35-11-8-31;/h4-5,12-14,16H,3,6-11,15H2,1-2H3,(H,29,33);1H
SMILES Code: O=C(NC(C)C)CN(C(C1=CC=C(F)C(Cl)=C1)=NC2=NC=C(OCCCN3CCOCC3)C=C24)C4=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 554.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Koga K, Nagai Y, Hanyu M, Yoshinaga M, Chaki S, Ohtake N, Ozaki S, Zhang MR, Suhara T, Higuchi M. High-contrast PET imaging of vasopressin V(1B) receptors with a novel radioligand, (11)C-TASP699. J Nucl Med. 2017 Apr 27. pii: jnumed.116.188698. doi: 10.2967/jnumed.116.188698. [Epub ahead of print] PubMed PMID: 28450560.
2: Iijima M, Yoshimizu T, Shimazaki T, Tokugawa K, Fukumoto K, Kurosu S, Kuwada T, Sekiguchi Y, Chaki S. Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol. 2014 Jul;171(14):3511-25. doi: 10.1111/bph.12699. PubMed PMID: 24654684; PubMed Central PMCID: PMC4105937.