WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525343
CAS#: 159026-30-9
Description: Aplysamine-1 is a histamine H3 receptor antagonist.
Hodoodo Cat#: H525343
Name: Aplysamine-1
CAS#: 159026-30-9
Chemical Formula: C15H24Br2N2O
Exact Mass: 406.03
Molecular Weight: 408.178
Elemental Analysis: C, 44.14; H, 5.93; Br, 39.15; N, 6.86; O, 3.92
This product is not in stock, which may be available by custom synthesis.
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Synonym: Aplysamine, Aplysamine-1
IUPAC/Chemical Name: 3-[2,6-dibromo-4-[2-(dimethylamino)ethyl]phenoxy]-N,N-dimethylpropan-1-amine
InChi Key: LWENJEAGCYZOBC-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H24Br2N2O/c1-18(2)7-5-9-20-15-13(16)10-12(11-14(15)17)6-8-19(3)4/h10-11H,5-9H2,1-4H3
SMILES Code: CN(C)CCCOC1=C(Br)C=C(CCN(C)C)C=C1Br
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 408.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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7: Yoshida M, Yamaguchi K. Total synthesis of dispyrin, purpurealidin E, and aplysamine-1. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1362-3. PubMed PMID: 18758122.
8: Buchanan MS, Carroll AR, Fechner GA, Boyle A, Simpson M, Addepalli R, Avery VM, Hooper JN, Cheung T, Chen H, Quinn RJ. Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp. J Nat Prod. 2008 Jun;71(6):1066-7. doi: 10.1021/np0706623. Epub 2008 Apr 5. PubMed PMID: 18393464.
9: Ortlepp S, Sjögren M, Dahlström M, Weber H, Ebel R, Edrada R, Thoms C, Schupp P, Bohlin L, Proksch P. Antifouling activity of bromotyrosine-derived sponge metabolites and synthetic analogues. Mar Biotechnol (NY). 2007 Nov-Dec;9(6):776-85. Epub 2007 Aug 23. PubMed PMID: 17713818.
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11: Sepcić K, Mancini I, Vidic I, Franssanito R, Pietra F, Macek P, Turk T. Antibacterial and anticholinesterase activities of aplysamine-4, a bromotyrosine-derived metabolite of a Red Sea marine sponge. J Nat Toxins. 2001 Aug;10(3):181-91. PubMed PMID: 11491458.
12: Venkateswarlu Y, Venkatesham U, Rao MR. Novel bromine-containing constituents of the sponge psammaplysilla purpurea1 . J Nat Prod. 1999 Jun;62(6):893-4. PubMed PMID: 10395512.
