LCAHA

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H525376

CAS#: 117094-40-3

Description: LCAHA is a novel inhibitor of USP2a, inhibiting growth of cyclin D1-dependent cells at submicromolar concentrations and being independent of p53 status.


Chemical Structure

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LCAHA
CAS# 117094-40-3

Theoretical Analysis

Hodoodo Cat#: H525376
Name: LCAHA
CAS#: 117094-40-3
Chemical Formula: C24H41NO3
Exact Mass: 391.31
Molecular Weight: 391.596
Elemental Analysis: C, 73.61; H, 10.55; N, 3.58; O, 12.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LCAHA

IUPAC/Chemical Name: Lithocholic acid hydroxyamide

InChi Key: WZXAGWREMCSWMF-YPLGJCPNSA-N

InChi Code: InChI=1S/C24H41NO3/c1-15(4-9-22(27)25-28)19-7-8-20-18-6-5-16-14-17(26)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,26,28H,4-14H2,1-3H3,(H,25,27)/t15-,16?,17-,18+,19-,20+,21+,23+,24-/m1/s1

SMILES Code: O[C@@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@H](C)CCC(NO)=O)CC[C@@]4([H])[C@]3([H])CCC2C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 391.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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5: Eftekharzadeh S, Sabetkish N, Sabetkish S, Kajbafzadeh AM. Comparing the bulking effect of calcium hydroxyapatite and Deflux injection into the bladder neck for improvement of urinary incontinence in bladder exstrophy-epispadias complex. Int Urol Nephrol. 2017 Feb;49(2):183-189. doi: 10.1007/s11255-016-1464-z. Epub 2016 Nov 28. PubMed PMID: 27896576.

6: Volobuev VV, Mandal PS, Galicka M, Caha O, Sánchez-Barriga J, Di Sante D, Varykhalov A, Khiar A, Picozzi S, Bauer G, Kacman P, Buczko R, Rader O, Springholz G. Giant Rashba Splitting in Pb(1-)(x) Sn(x) Te (111) Topological Crystalline Insulator Films Controlled by Bi Doping in the Bulk. Adv Mater. 2017 Jan;29(3). doi: 10.1002/adma.201604185. Epub 2016 Nov 17. PubMed PMID: 27859857.

7: Rousidou C, Karaiskos D, Myti D, Karanasios E, Karas PA, Tourna M, Tzortzakakis EA, Karpouzas DG. Distribution and function of carbamate hydrolase genes cehA and mcd in soils: the distinct role of soil pH. FEMS Microbiol Ecol. 2017 Jan 1;93(1). doi: 10.1093/femsec/fiw219. PubMed PMID: 27797966.

8: Akrap A, Hakl M, Tchoumakov S, Crassee I, Kuba J, Goerbig MO, Homes CC, Caha O, Novák J, Teppe F, Desrat W, Koohpayeh S, Wu L, Armitage NP, Nateprov A, Arushanov E, Gibson QD, Cava RJ, van der Marel D, Piot BA, Faugeras C, Martinez G, Potemski M, Orlita M. Magneto-Optical Signature of Massless Kane Electrons in Cd_{3}As_{2}. Phys Rev Lett. 2016 Sep 23;117(13):136401. Epub 2016 Sep 21. PubMed PMID: 27715109.

9: Rey de Castro J, Liendo A, Ortiz O, Rosales-Mayor E, Liendo C. Ventilatory Cycle Measurements and Loop Gain in Central Apnea in Mining Drivers Exposed to Intermittent Altitude. J Clin Sleep Med. 2017 Jan 15;13(1):27-32. doi: 10.5664/jcsm.6380. PubMed PMID: 27707449; PubMed Central PMCID: PMC5181610.

10: Fabi SG, Burgess C, Carruthers A, Carruthers J, Day D, Goldie K, Kerscher M, Nikolis A, Pavicic T, Rho NK, Rzany B, Sattler S, Seo K, Werschler WP, Sattler G. Consensus Recommendations for Combined Aesthetic Interventions Using Botulinum Toxin, Fillers, and Microfocused Ultrasound in the Neck, Décolletage, Hands, and Other Areas of the Body. Dermatol Surg. 2016 Oct;42(10):1199-1208. PubMed PMID: 27668925.

11: Aguilera SB, Aristizabal M, Reed A. Successful Treatment of Calcium Hydroxylapatite Nodules With Intralesional 5-Fluorouracil, Dexamethasone, and Triamcinolone. J Drugs Dermatol. 2016 Sep 1;15(9):1142-3. PubMed PMID: 27602980.

12: Meland M, Groppi C, Lorenc ZP. Rheological Properties of Calcium Hydroxylapatite With Integral Lidocaine. J Drugs Dermatol. 2016 Sep 1;15(9):1107-10. PubMed PMID: 27602973.

13: Caffier PP, I Nasr A, Weikert S, Rummich J, Gross M, Nawka T. The use of injectable calcium hydroxylapatite in the surgically pretreated larynx with glottal insufficiency. Laryngoscope. 2017 May;127(5):1125-1130. doi: 10.1002/lary.26261. Epub 2016 Aug 31. PubMed PMID: 27578371.

14: Schachter D, Bertucci V, Solish N. Calcium Hydroxylapatite With Integral Lidocaine Provides Improved Pain Control for the Correction of Nasolabial Folds. J Drugs Dermatol. 2016 Aug 1;15(8):1005-10. PubMed PMID: 27538003.

15: Lee JC, Lorenc ZP. Synthetic Fillers for Facial Rejuvenation. Clin Plast Surg. 2016 Jul;43(3):497-503. doi: 10.1016/j.cps.2016.03.002. Review. PubMed PMID: 27363763.

16: Tavares-da-Silva EJ, Varela CL, Pires AS, Encarnação JC, Abrantes AM, Botelho MF, Carvalho RA, Proença C, Freitas M, Fernandes E, Roleira FM. Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives. Bioorg Med Chem. 2016 Aug 15;24(16):3556-64. doi: 10.1016/j.bmc.2016.05.065. Epub 2016 May 30. PubMed PMID: 27290693.

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18: Shi XH, Zhou X, Zhang YM, Lei ZY, Liu T, Fan DL. Complications from Nasolabial Fold Injection of Calcium Hydroxylapatite for Facial Soft-Tissue Augmentation: A Systematic Review and Meta-Analysis. Aesthet Surg J. 2016 Jun;36(6):712-7. doi: 10.1093/asj/sjv206. Review. PubMed PMID: 27178901.

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20: Courderot-Masuyer C, Robin S, Tauzin H, Humbert P. Evaluation of lifting and antiwrinkle effects of calcium hydroxylapatite filler. In vitro quantification of contractile forces of human wrinkle and normal aged fibroblasts treated with calcium hydroxylapatite. J Cosmet Dermatol. 2016 Sep;15(3):260-8. doi: 10.1111/jocd.12215. Epub 2016 Mar 17. PubMed PMID: 26990784.