WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525635
CAS#: 2084867-65-0
Description: Capzimin is a novel potent and specific inhibitor of proteasome isopeptidase Rpn11.
Hodoodo Cat#: H525635
Name: Capzimin
CAS#: 2084867-65-0
Chemical Formula: C15H13N3OS2
Exact Mass: 315.05
Molecular Weight: 315.409
Elemental Analysis: C, 57.12; H, 4.15; N, 13.32; O, 5.07; S, 20.33
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Synonym: Capzimin
IUPAC/Chemical Name: 8-Mercapto-N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide
InChi Key: MYNGHZGMRXNEEH-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H13N3OS2/c19-15(17-5-4-13-16-6-7-21-13)11-8-10-2-1-3-12(20)14(10)18-9-11/h1-3,6-9,20H,4-5H2,(H,17,19)
SMILES Code: O=C(C1=CC2=CC=CC(S)=C2N=C1)NCCC3=NC=CS3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 315.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Li J, Yakushi T, Parlati F, Mackinnon AL, Perez C, Ma Y, Carter KP, Colayco S, Magnuson G, Brown B, Nguyen K, Vasile S, Suyama E, Smith LH, Sergienko E, Pinkerton AB, Chung TDY, Palmer AE, Pass I, Hess S, Cohen SM, Deshaies RJ. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017 May;13(5):486-493. doi: 10.1038/nchembio.2326. Epub 2017 Feb 28. PubMed PMID: 28244987.