WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525920
CAS#: 1056468-55-3
Description: LP117 is a novel drug-specific modulator of ABCB1-mediated drug transport.
Hodoodo Cat#: H525920
Name: LP117
CAS#: 1056468-55-3
Chemical Formula: C21H23ClN4O2S
Exact Mass: 430.12
Molecular Weight: 430.951
Elemental Analysis: C, 58.53; H, 5.38; Cl, 8.23; N, 13.00; O, 7.42; S, 7.44
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Synonym: LP117
IUPAC/Chemical Name: Ethyl 2-((4-chloro-6-(quinolin-6-ylamino)pyrimidin-2-yl)thio)hexanoate
InChi Key: PGDAEUTURQTTPZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H23ClN4O2S/c1-3-5-8-17(20(27)28-4-2)29-21-25-18(22)13-19(26-21)24-15-9-10-16-14(12-15)7-6-11-23-16/h6-7,9-13,17H,3-5,8H2,1-2H3,(H,24,25,26)
SMILES Code: CCCCC(SC1=NC(NC2=CC=C3N=CC=CC3=C2)=CC(Cl)=N1)C(OCC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 430.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Michaelis M, Rothweiler F, Wurglics M, Aniceto N, Dittrich M, Zettl H, Wiese M, Wass M, Ghafourian T, Schubert-Zsilavecz M, Cinatl J. Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport. Oncotarget. 2016 Mar 8;7(10):11664-76. doi: 10.18632/oncotarget.7345. PubMed PMID: 26887049; PubMed Central PMCID: PMC4905501.
2: White JA, Ziv I, Cleary LJ, Baxter DA, Byrne JH. The role of interneurons in controlling the tail-withdrawal reflex in Aplysia: a network model. J Neurophysiol. 1993 Nov;70(5):1777-86. PubMed PMID: 8294952.
3: Cleary LJ, Byrne JH. Identification and characterization of a multifunction neuron contributing to defensive arousal in Aplysia. J Neurophysiol. 1993 Nov;70(5):1767-76. PubMed PMID: 8294951.