LP117

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H525920

CAS#: 1056468-55-3

Description: LP117 is a novel drug-specific modulator of ABCB1-mediated drug transport.


Chemical Structure

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LP117
CAS# 1056468-55-3

Theoretical Analysis

Hodoodo Cat#: H525920
Name: LP117
CAS#: 1056468-55-3
Chemical Formula: C21H23ClN4O2S
Exact Mass: 430.12
Molecular Weight: 430.951
Elemental Analysis: C, 58.53; H, 5.38; Cl, 8.23; N, 13.00; O, 7.42; S, 7.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: LP117

IUPAC/Chemical Name: Ethyl 2-((4-chloro-6-(quinolin-6-ylamino)pyrimidin-2-yl)thio)hexanoate

InChi Key: PGDAEUTURQTTPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23ClN4O2S/c1-3-5-8-17(20(27)28-4-2)29-21-25-18(22)13-19(26-21)24-15-9-10-16-14(12-15)7-6-11-23-16/h6-7,9-13,17H,3-5,8H2,1-2H3,(H,24,25,26)

SMILES Code: CCCCC(SC1=NC(NC2=CC=C3N=CC=CC3=C2)=CC(Cl)=N1)C(OCC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Michaelis M, Rothweiler F, Wurglics M, Aniceto N, Dittrich M, Zettl H, Wiese M, Wass M, Ghafourian T, Schubert-Zsilavecz M, Cinatl J. Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport. Oncotarget. 2016 Mar 8;7(10):11664-76. doi: 10.18632/oncotarget.7345. PubMed PMID: 26887049; PubMed Central PMCID: PMC4905501.

2: White JA, Ziv I, Cleary LJ, Baxter DA, Byrne JH. The role of interneurons in controlling the tail-withdrawal reflex in Aplysia: a network model. J Neurophysiol. 1993 Nov;70(5):1777-86. PubMed PMID: 8294952.

3: Cleary LJ, Byrne JH. Identification and characterization of a multifunction neuron contributing to defensive arousal in Aplysia. J Neurophysiol. 1993 Nov;70(5):1767-76. PubMed PMID: 8294951.