WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525965
CAS#: 1637667-18-5
Description: X-34 is a highly fluorescent amyloid-specific dye, exhibiting inclusion bodies that were amyloid-like aggregates by virtue of their staining.
Hodoodo Cat#: H525965
Name: X-34
CAS#: 1637667-18-5
Chemical Formula: C24H16Na2O6
Exact Mass: 446.07
Molecular Weight: 446.366
Elemental Analysis: C, 64.58; H, 3.61; Na, 10.30; O, 21.51
This product is not in stock, which may be available by custom synthesis.
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Synonym: X-34, X 34, X34
IUPAC/Chemical Name: Disodium 2-carboxy-4-[(E)-2-[4-[(E)-2-(3-carboxy-4-oxidophenyl)ethenyl]phenyl]ethenyl]phenolate
InChi Key: OIRVPTCFABGCQX-ZHINHYBUSA-L
InChi Code: InChI=1S/C24H18O6.2Na/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30;;/h1-14,25-26H,(H,27,28)(H,29,30);;/q;2*+1/p-2/b7-5+,8-6+;;
SMILES Code: [O-]C1=CC=C(/C=C/C2=CC=C(/C=C/C3=CC=C([O-])C(C(O)=O)=C3)C=C2)C=C1C(O)=O.[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 446.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: van Stam G, Kok HP, Hulshof MCCM, Kolff MW, van Tienhoven G, Sijbrands J, Bakker A, Zum Vörde Sive Vörding PJ, Oldenborg S, de Greef M, Rasch CRN, Crezee H. A flexible 70 MHz phase-controlled double waveguide system for hyperthermia treatment of superficial tumours with deep infiltration. Int J Hyperthermia. 2017 Apr 18:1-14. doi: 10.1080/02656736.2017.1313460. [Epub ahead of print] PubMed PMID: 28540800.
2: Kim J, An H, Seo Y, Jung Y, Lee JS, Choi N, Bong KW. Flow lithography in ultraviolet-curable polydimethylsiloxane microfluidic chips. Biomicrofluidics. 2017 Apr 27;11(2):024120. doi: 10.1063/1.4982698. eCollection 2017 Mar. PubMed PMID: 28469763; PubMed Central PMCID: PMC5407903.
3: Muranushi R, Suzuki M, Araki K, Kubo N, Otake S, Nishida Y, Ishige T, Arakawa H, Kuwano H, Shirabe K. Successful hepatectomy for hepatic abscess with chronic granulomatous disease: a case report. Surg Case Rep. 2017 Dec;3(1):57. doi: 10.1186/s40792-017-0333-z. Epub 2017 Apr 26. PubMed PMID: 28447322; PubMed Central PMCID: PMC5406309.
4: LeVine H 3rd, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017 Jun;54:163-169. doi: 10.1016/j.neurobiolaging.2017.03.005. Epub 2017 Mar 14. PubMed PMID: 28385551.
5: Rizwan M, Aslam M, Asghar MJ, Abbas G, Shah TM, Shimelis H. Pre-breeding of lentil (Lens culinaris Medik.) for herbicide resistance through seed mutagenesis. PLoS One. 2017 Feb 14;12(2):e0171846. doi: 10.1371/journal.pone.0171846. eCollection 2017. PubMed PMID: 28196091; PubMed Central PMCID: PMC5308809.
6: Jacques MF, Orme P, Smith J, Morse CI. Resting Energy Expenditure in Adults with Becker's Muscular Dystrophy. PLoS One. 2017 Jan 6;12(1):e0169848. doi: 10.1371/journal.pone.0169848. eCollection 2017. PubMed PMID: 28060911; PubMed Central PMCID: PMC5218559.
7: Ghalia MA, Dahman Y. Investigating the effect of multi-functional chain extenders on PLA/PEG copolymer properties. Int J Biol Macromol. 2017 Feb;95:494-504. doi: 10.1016/j.ijbiomac.2016.11.003. Epub 2016 Nov 10. PubMed PMID: 27840219.
8: Morrocchi M, Hunter WC, Del Guerra A, Lewellen TK, Kinahan PE, MacDonald LR, Bisogni MG, Miyaoka RS. Evaluation of event position reconstruction in monolithic crystals that are optically coupled. Phys Med Biol. 2016 Dec 7;61(23):8298-8320. Epub 2016 Nov 3. PubMed PMID: 27811385; PubMed Central PMCID: PMC5132859.
9: Bäck M, Appelqvist H, LeVine H 3rd, Nilsson KP. Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ. Chemistry. 2016 Dec 19;22(51):18335-18338. doi: 10.1002/chem.201604583. Epub 2016 Nov 3. PubMed PMID: 27767229; PubMed Central PMCID: PMC5215536.
10: Huang BT, Lin Z, Lin PX, Lu JY, Chen CZ. Radiobiological modeling of two stereotactic body radiotherapy schedules in patients with stage I peripheral non-small cell lung cancer. Oncotarget. 2016 Jun 28;7(26):40746-40755. doi: 10.18632/oncotarget.9442. PubMed PMID: 27203739; PubMed Central PMCID: PMC5130041.
11: Matyagin YV, Collins PJ. Effectiveness of abdominal shields in chest radiography: a Monte Carlo evaluation. Br J Radiol. 2016 Oct;89(1066):20160465. doi: 10.1259/bjr.20160465. Epub 2016 Aug 9. PubMed PMID: 27504913; PubMed Central PMCID: PMC5124812.
12: Mi Z, Halfter W, Abrahamson EE, Klunk WE, Mathis CA, Mufson EJ, Ikonomovic MD. Tenascin-C Is Associated with Cored Amyloid-β Plaques in Alzheimer Disease and Pathology Burdened Cognitively Normal Elderly. J Neuropathol Exp Neurol. 2016 Sep;75(9):868-76. doi: 10.1093/jnen/nlw062. Epub 2016 Jul 21. PubMed PMID: 27444354.
13: Arai T, Ohno A, Kazunori M, Kakizawa T, Kuwata H, Ozawa T, Shibanuma M, Hara S, Ishida S, Kurihara M, Miyata N, Nakagawa H, Fukuhara K. Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease. Bioorg Med Chem. 2016 Sep 15;24(18):4138-43. doi: 10.1016/j.bmc.2016.06.057. Epub 2016 Jun 30. PubMed PMID: 27407032.
14: Koenka IJ, Küng N, Kubáň P, Chwalek T, Furrer G, Wehrli B, Müller B, Hauser PC. Thermostatted dual-channel portable capillary electrophoresis instrument. Electrophoresis. 2016 Sep;37(17-18):2368-75. doi: 10.1002/elps.201600235. Epub 2016 Jul 4. PubMed PMID: 27296618.
15: Lin RP, Weitzel EK, Chen PG, McMains KC, Chang DR, Braxton EE, Majors J, Bunegin L. Failure pressures after repairs of 2-cm × 2.5-cm rhinologic dural defects in a porcine ex vivo model. Int Forum Allergy Rhinol. 2016 Oct;6(10):1034-1039. doi: 10.1002/alr.21804. Epub 2016 Jun 9. PubMed PMID: 27277389.
16: Wu Y, Pan M, Dai Y, Liu B, Cui J, Shi W, Qiu Q, Huang W, Qian H. Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors. Bioorg Med Chem. 2016 May 15;24(10):2287-97. doi: 10.1016/j.bmc.2016.03.065. Epub 2016 Apr 1. PubMed PMID: 27073052.
17: Vallino Costassa E, Fiorini M, Zanusso G, Peletto S, Acutis P, Baioni E, Maurella C, Tagliavini F, Catania M, Gallo M, Faro ML, Chieppa MN, Meloni D, D'Angelo A, Paciello O, Ghidoni R, Tonoli E, Casalone C, Corona C. Characterization of Amyloid-β Deposits in Bovine Brains. J Alzheimers Dis. 2016;51(3):875-87. doi: 10.3233/JAD-151007. PubMed PMID: 26890772; PubMed Central PMCID: PMC4927890.
18: Lo Monte G, Piva I, Graziano A, Engl B, Marci R. Ulipristal acetate prior to in vitro fertilization in a female patient affected by uterine fibroids: a case report. Eur Rev Med Pharmacol Sci. 2016;20(2):202-7. PubMed PMID: 26875885.
19: Alawi SA, Bohr S, Stromps JP, Alharbi Z, Pallua N. [Research Assessment in Plastic and Reconstructive Surgery on a National Level: A 5-Years Systematic Review of Research Activity in German University Hospitals]. Handchir Mikrochir Plast Chir. 2016 Apr;48(2):73-7. doi: 10.1055/s-0041-109770. Epub 2016 Feb 2. Review. German. PubMed PMID: 26837495.
20: Zhu Y, Chang J, Niu YJ, Chen WL, Du XY. Novel ultra-thin near-eye augmented-view device (UNAD). Opt Express. 2016 Jan 25;24(2):1305-13. doi: 10.1364/OE.24.001305. PubMed PMID: 26832511.
