WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526033
CAS#: 131615-52-6
Description: TISCH is a potent and selective iodinated ligand for CNS D1 dopamine receptor.
Hodoodo Cat#: H526033
Name: TISCH
CAS#: 131615-52-6
Chemical Formula: C17H17ClINO
Exact Mass: 413.00
Molecular Weight: 413.684
Elemental Analysis: C, 49.36; H, 4.14; Cl, 8.57; I, 30.68; N, 3.39; O, 3.87
This product is not in stock, which may be available by custom synthesis.
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Synonym: TISCH
IUPAC/Chemical Name: (R)-8-Chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-1H-3-benzazepin-7-ol
InChi Key: DUTJKDUWCSYNLM-OAHLLOKOSA-N
InChi Code: InChI=1S/C17H17ClINO/c1-20-6-5-12-8-16(18)17(21)9-14(12)15(10-20)11-3-2-4-13(19)7-11/h2-4,7-9,15,21H,5-6,10H2,1H3/t15-/m1/s1
SMILES Code: OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC(I)=C3)C2=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 413.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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19: Masuda K, Ono A, Aikata H, Kawaoka T, Nelson Hayes C, Teraoka Y, Daijo K, Nakamura-Inagaki Y, Morio K, Fujino H, Kan H, Uchida T, Masaki K, Kobayashi T, Nakahara T, Makokha GN, Zhang Y, Nagaoki Y, Miki D, Tsuge M, Hiramatsu A, Imamura M, Abe-Chayama H, Kawakami Y, Ochi H, Chayama K. Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy. J Gastroenterol. 2017 May 4. doi: 10.1007/s00535-017-1348-8. [Epub ahead of print] Erratum in: J Gastroenterol. 2017 May 29;:. PubMed PMID: 28474222.
20: Narloch JL, Farber SH, Sammons S, McSherry F, Herndon JE 2nd, Hoang JK, Yin FF, Sampson JH, Fecci PE, Blackwell KL, Kirkpatrick JP, Kim GJ. Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis. Neuro Oncol. 2017 May 3. doi: 10.1093/neuonc/nox090. [Epub ahead of print] PubMed PMID: 28472527.