WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526043
CAS#: 264206-85-1
Description: GSK3987 is a potent and specific liver X receptor (LXR) dual agonist of LXRalpha and LXRbeta.
Hodoodo Cat#: H526043
Name: GSK3987
CAS#: 264206-85-1
Chemical Formula: C24H20N2O3
Exact Mass: 384.15
Molecular Weight: 384.435
Elemental Analysis: C, 74.98; H, 5.24; N, 7.29; O, 12.49
This product is not in stock, which may be available by custom synthesis.
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Synonym: GSK3987
IUPAC/Chemical Name: 1-Benzyl-3-(4-methoxyanilino)-4-phenylpyrrole-2,5-dione
InChi Key: HLZMYWLMBBLASX-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H20N2O3/c1-29-20-14-12-19(13-15-20)25-22-21(18-10-6-3-7-11-18)23(27)26(24(22)28)16-17-8-4-2-5-9-17/h2-15,25H,16H2,1H3
SMILES Code: O=C(C(NC1=CC=C(OC)C=C1)=C2C3=CC=CC=C3)N(CC4=CC=CC=C4)C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 384.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ranganathan PV, Jayakumar C, Ramesh G. Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization. Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F948-57. doi: 10.1152/ajprenal.00580.2012. Epub 2013 Feb 13. PubMed PMID: 23408164; PubMed Central PMCID: PMC3625850.
2: Lin HR. Paeoniflorin acts as a liver X receptor agonist. J Asian Nat Prod Res. 2013;15(1):35-45. doi: 10.1080/10286020.2012.742510. Epub 2013 Jan 3. PubMed PMID: 23281636.
3: Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure. J Med Chem. 2005 Aug 25;48(17):5419-22. PubMed PMID: 16107141.