WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526047
CAS#: 6837-93-0
Description: NSC16168 is a specific inhibitor of ERCC1-XPF with no effect on both HhaI and XPG.
Hodoodo Cat#: H526047
Name: NSC16168
CAS#: 6837-93-0
Chemical Formula: C17H15NO9S3
Exact Mass: 472.99
Molecular Weight: 473.485
Elemental Analysis: C, 43.12; H, 3.19; N, 2.96; O, 30.41; S, 20.31
Synonym: NSC16168
IUPAC/Chemical Name: 4-Amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
InChi Key: ZIQWUYNDHGXLIN-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H15NO9S3/c1-10-2-4-12(5-3-10)30(25,26)27-16-9-14(29(22,23)24)7-11-6-13(28(19,20)21)8-15(18)17(11)16/h2-9H,18H2,1H3,(H,19,20,21)(H,22,23,24)
SMILES Code: O=S(C1=CC(N)=C2C(OS(=O)(C3=CC=C(C)C=C3)=O)=CC(S(=O)(O)=O)=CC2=C1)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 473.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Arora S, Heyza J, Zhang H, Kalman-Maltese V, Tillison K, Floyd AM, Chalfin EM, Bepler G, Patrick SM. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117. doi: 10.18632/oncotarget.12072. PubMed PMID: 27650543; PubMed Central PMCID: PMC5342726.