WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526128
CAS#: 77202-28-9
Description: LOM612 is a novel Activator of FOXO Nuclear-Cytoplasmic Shuttling, inducing nuclear translocation of a FOXO3a reporter protein as well as endogenous FOXO3a and FOXO1 in U2OS cells in a dose-dependent manner.
Hodoodo Cat#: H526128
Name: LOM612
CAS#: 77202-28-9
Chemical Formula: C17H9NO2S
Exact Mass: 291.04
Molecular Weight: 291.324
Elemental Analysis: C, 70.09; H, 3.11; N, 4.81; O, 10.98; S, 11.00
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Synonym: LOM612
IUPAC/Chemical Name: 3-Phenyl-naphtho[2,3-d]isothiazole-4,9-dione
InChi Key: LKMDHRKGPJJYEI-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H9NO2S/c19-15-11-8-4-5-9-12(11)16(20)17-13(15)14(18-21-17)10-6-2-1-3-7-10/h1-9H
SMILES Code: O=C(C1=C2SN=C1C3=CC=CC=C3)C4=C(C=CC=C4)C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 291.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodriguez Quesada L, Machado S, Vicente F, Dallavalle S, Link W. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491. doi: 10.1371/journal.pone.0167491. eCollection 2016. PubMed PMID: 27936162; PubMed Central PMCID: PMC5147912.