Pyrabactin
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H526291

CAS#: 419538-69-5

Description: Pyrabactin is a plant growth inhibitor, acting as a seed-selective abscisic acid (ABA) agonist. Pyrabctin is a novel PYL agonist.

Chemical Structure

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Pyrabactin
CAS# 419538-69-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H526291
Name: Pyrabactin
CAS#: 419538-69-5
Chemical Formula: C16H13BrN2O2S
Exact Mass: 375.99
Molecular Weight: 377.256
Elemental Analysis: C, 50.94; H, 3.47; Br, 21.18; N, 7.43; O, 8.48; S, 8.50

Price and Availability

Size Price Availability Quantity
10mg USD 250 2 Weeks
20mg USD 450 2 Weeks
50mg USD 950 2 Weeks
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Synonym: Pyrabactin

IUPAC/Chemical Name: 4-Bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide

InChi Key: GJSDYQXOSHKOGX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H13BrN2O2S/c17-15-8-9-16(14-7-2-1-6-13(14)15)22(20,21)19-11-12-5-3-4-10-18-12/h1-10,19H,11H2

SMILES Code: O=S(C1=C2C=CC=CC2=C(Br)C=C1)(NCC3=NC=CC=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 377.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: González-Villagra J, Kurepin LV, Reyes-Díaz MM. Evaluating the involvement and interaction of abscisic acid and miRNA156 in the induction of anthocyanin biosynthesis in drought-stressed plants. Planta. 2017 May 22. doi: 10.1007/s00425-017-2711-y. [Epub ahead of print] Review. PubMed PMID: 28534253.

2: Li Y, Wang D, Sun C, Hu X, Mu X, Hu J, Yang Y, Zhang Y, Xie CG, Zhou X. Molecular characterization of an AtPYL1-like protein, BrPYL1, as a putative ABA receptor in Brassica rapa. Biochem Biophys Res Commun. 2017 Jun 3;487(3):684-689. doi: 10.1016/j.bbrc.2017.04.116. Epub 2017 Apr 24. PubMed PMID: 28450111.

3: Takahashi Y, Ebisu Y, Shimazaki KI. Reconstitution of Abscisic Acid Signaling from the Receptor to DNA via bHLH Transcription Factors. Plant Physiol. 2017 Jun;174(2):815-822. doi: 10.1104/pp.16.01825. Epub 2017 Apr 24. PubMed PMID: 28438792.

4: Yu J, Yang L, Liu X, Tang R, Wang Y, Ge H, Wu M, Zhang J, Zhao F, Luan S, Lan W. Overexpression of Poplar Pyrabactin Resistance-Like Abscisic Acid Receptors Promotes Abscisic Acid Sensitivity and Drought Resistance in Transgenic Arabidopsis. PLoS One. 2016 Dec 19;11(12):e0168040. doi: 10.1371/journal.pone.0168040. eCollection 2016. PubMed PMID: 27992471; PubMed Central PMCID: PMC5167274.

5: Chen J, Yu F, Liu Y, Du C, Li X, Zhu S, Wang X, Lan W, Rodriguez PL, Liu X, Li D, Chen L, Luan S. FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in Arabidopsis. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5519-27. doi: 10.1073/pnas.1608449113. Epub 2016 Aug 26. PubMed PMID: 27566404; PubMed Central PMCID: PMC5027425.

6: Miret JA, Munné-Bosch S. Abscisic acid and pyrabactin improve vitamin C contents in raspberries. Food Chem. 2016 Jul 15;203:216-23. doi: 10.1016/j.foodchem.2016.02.046. Epub 2016 Feb 6. PubMed PMID: 26948608.

7: Zhao Y, Chan Z, Gao J, Xing L, Cao M, Yu C, Hu Y, You J, Shi H, Zhu Y, Gong Y, Mu Z, Wang H, Deng X, Wang P, Bressan RA, Zhu JK. ABA receptor PYL9 promotes drought resistance and leaf senescence. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1949-54. doi: 10.1073/pnas.1522840113. Epub 2016 Feb 1. PubMed PMID: 26831097; PubMed Central PMCID: PMC4763734.

8: Diaz M, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Rodriguez L, Fernandez D, Antoni R, Yunta C, Belda-Palazon B, Gonzalez-Guzman M, Peirats-Llobet M, Menendez M, Boskovic J, Marquez JA, Rodriguez PL, Albert A. Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E396-405. doi: 10.1073/pnas.1512779113. Epub 2015 Dec 30. PubMed PMID: 26719420; PubMed Central PMCID: PMC4725540.

9: Helander JD, Vaidya AS, Cutler SR. Chemical manipulation of plant water use. Bioorg Med Chem. 2016 Feb 1;24(3):493-500. doi: 10.1016/j.bmc.2015.11.010. Epub 2015 Nov 11. Review. PubMed PMID: 26612713.

10: Li Y, Zhang L, Li D, Liu Z, Wang J, Li X, Yang Y. The Arabidopsis F-box E3 ligase RIFP1 plays a negative role in abscisic acid signalling by facilitating ABA receptor RCAR3 degradation. Plant Cell Environ. 2016 Mar;39(3):571-82. doi: 10.1111/pce.12639. Epub 2015 Dec 11. PubMed PMID: 26386272.

11: Tian X, Wang Z, Li X, Lv T, Liu H, Wang L, Niu H, Bu Q. Characterization and Functional Analysis of Pyrabactin Resistance-Like Abscisic Acid Receptor Family in Rice. Rice (N Y). 2015 Dec;8(1):28. doi: 10.1186/s12284-015-0061-6. Epub 2015 Sep 11. PubMed PMID: 26362328; PubMed Central PMCID: PMC4567572.

12: Castillo MC, Lozano-Juste J, González-Guzmán M, Rodriguez L, Rodriguez PL, León J. Inactivation of PYR/PYL/RCAR ABA receptors by tyrosine nitration may enable rapid inhibition of ABA signaling by nitric oxide in plants. Sci Signal. 2015 Sep 1;8(392):ra89. doi: 10.1126/scisignal.aaa7981. PubMed PMID: 26329583.

13: Waadt R, Manalansan B, Rauniyar N, Munemasa S, Booker MA, Brandt B, Waadt C, Nusinow DA, Kay SA, Kunz HH, Schumacher K, DeLong A, Yates JR 3rd, Schroeder JI. Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses. Plant Physiol. 2015 Sep;169(1):760-79. doi: 10.1104/pp.15.00575. Epub 2015 Jul 14. PubMed PMID: 26175513; PubMed Central PMCID: PMC4577397.

14: Takeuchi J, Ohnishi T, Okamoto M, Todoroki Y. The selectivity of 6-nor-ABA and 7'-nor-ABA for abscisic acid receptor subtypes. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3507-10. doi: 10.1016/j.bmcl.2015.06.088. Epub 2015 Jul 3. PubMed PMID: 26174552.

15: Lim CW, Baek W, Jung J, Kim JH, Lee SC. Function of ABA in Stomatal Defense against Biotic and Drought Stresses. Int J Mol Sci. 2015 Jul 6;16(7):15251-70. doi: 10.3390/ijms160715251. Review. PubMed PMID: 26154766; PubMed Central PMCID: PMC4519898.

16: Peskan-Berghöfer T, Vilches-Barro A, Müller TM, Glawischnig E, Reichelt M, Gershenzon J, Rausch T. Sustained exposure to abscisic acid enhances the colonization potential of the mutualist fungus Piriformospora indica on Arabidopsis thaliana roots. New Phytol. 2015 Nov;208(3):873-86. doi: 10.1111/nph.13504. Epub 2015 Jun 15. PubMed PMID: 26075497.

17: Fan W, Li J, Jia J, Wang F, Cao C, Hu J, Mu Z. Pyrabactin regulates root hydraulic properties in maize seedlings by affecting PIP aquaporins in a phosphorylation-dependent manner. Plant Physiol Biochem. 2015 Sep;94:28-34. doi: 10.1016/j.plaphy.2015.05.005. Epub 2015 May 15. PubMed PMID: 26000467.

18: Lee HN, Lee KH, Kim CS. Abscisic acid receptor PYRABACTIN RESISTANCE-LIKE 8, PYL8, is involved in glucose response and dark-induced leaf senescence in Arabidopsis. Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):24-8. doi: 10.1016/j.bbrc.2015.05.010. Epub 2015 May 15. PubMed PMID: 25983319.

19: Yamburenko MV, Zubo YO, Börner T. Abscisic acid affects transcription of chloroplast genes via protein phosphatase 2C-dependent activation of nuclear genes: repression by guanosine-3'-5'-bisdiphosphate and activation by sigma factor 5. Plant J. 2015 Jun;82(6):1030-41. doi: 10.1111/tpj.12876. PubMed PMID: 25976841.

20: Yoshida T, Mogami J, Yamaguchi-Shinozaki K. Omics Approaches Toward Defining the Comprehensive Abscisic Acid Signaling Network in Plants. Plant Cell Physiol. 2015 Jun;56(6):1043-52. doi: 10.1093/pcp/pcv060. Epub 2015 Apr 26. Review. PubMed PMID: 25917608.