WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526295
CAS#: 482333-74-4 (1-methylimidazole)
Description: Saccharin 1-methylimidazole, also known as SMI, is a chemical activator commonly used in solid-phase synthesis of DNA and RNA oligonucleotides. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA oligonucleotides that are resistant to nuclease digestion.
Hodoodo Cat#: H526295
Name: Saccharin 1-methylimidazole
CAS#: 482333-74-4 (1-methylimidazole)
Chemical Formula: C11H11N3O3S
Exact Mass: 265.05
Molecular Weight: 265.287
Elemental Analysis: C, 49.80; H, 4.18; N, 15.84; O, 18.09; S, 12.09
Related CAS #: 82385-42-0 (sodium salt hydrate) 128-44-9 (sodium) 482333-74-4 (1-methylimidazole)
Synonym: Saccharin 1-methylimidazole; SMI;
IUPAC/Chemical Name: 1,1-Dioxide-1,2-benzisothiazol-3(2H)-one 1-methyl-1H-imidazole salt
InChi Key: DMSNKRPEUQVMNF-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H5NO3S.C4H6N2/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;1-6-3-2-5-4-6/h1-4H,(H,8,9);2-4H,1H3
SMILES Code: O=S(C1=C(C=CC=C1)C2=O)(N2)=O.CN3C=NC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, DMF, and ethanol
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.7 | 198.54 | |
| Water | 53.0 | 199.78 | |
| Ethanol | 31.5 | 118.74 | |
| DMF | 5.0 | 18.85 | |
| PBS (pH 7.2) | 10.0 | 37.69 |
The following data is based on the product molecular weight 265.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
