WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526296
CAS#: 60925-00-0
Description: Apoptosis inducer 5d is a novel inducer of cell death by activating apoptosis in cancer cells.
Hodoodo Cat#: H526296
Name: Apoptosis inducer 5d
CAS#: 60925-00-0
Chemical Formula: C20H14BrN3
Exact Mass: 375.04
Molecular Weight: 376.257
Elemental Analysis: C, 63.84; H, 3.75; Br, 21.24; N, 11.17
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Synonym: Apoptosis inducer 5d
IUPAC/Chemical Name: 3-[1-(4-Bromo-phenyl)-5-phenyl-1H-pyrazol-3-yl]-pyridine
InChi Key: TZHWETVMXQTIER-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14BrN3/c21-17-8-10-18(11-9-17)24-20(15-5-2-1-3-6-15)13-19(23-24)16-7-4-12-22-14-16/h1-14H
SMILES Code: BrC1=CC=C(N2N=C(C3=CC=CN=C3)C=C2C4=CC=CC=C4)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 376.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fernández-Laso V, Sastre C, Valdivielso JM, Betriu A, Fernández E, Egido J, Martín-Ventura JL, Blanco-Colio LM. Soluble TWEAK and Major Adverse Cardiovascular Events in Patients with CKD. Clin J Am Soc Nephrol. 2016 Mar 7;11(3):413-22. doi: 10.2215/CJN.07900715. Epub 2016 Jan 4. PubMed PMID: 26728587; PubMed Central PMCID: PMC4791813.
2: Kemnitzer W, Sirisoma N, May C, Tseng B, Drewe J, Cai SX. Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3536-40. doi: 10.1016/j.bmcl.2009.04.145. Epub 2009 May 5. PubMed PMID: 19464890.
3: Drewe J, Kasibhatla S, Tseng B, Shelton E, Sperandio D, Yee RM, Litvak J, Sendzik M, Spencer JR, Cai SX. Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-th iazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4987-90. Epub 2007 Jun 6. PubMed PMID: 17562361.
