Erysolin
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H540122

CAS#: 504-84-7

Description: Erysolin is a sulforaphane analog found in cruciferous vegetables. It induces phase II enzyme activity and inhibits growth of colon cancer cells.

Chemical Structure

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Erysolin
CAS# 504-84-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H540122
Name: Erysolin
CAS#: 504-84-7
Chemical Formula: C6H11NO2S2
Exact Mass: 193.02
Molecular Weight: 193.270
Elemental Analysis: C, 37.29; H, 5.74; N, 7.25; O, 16.56; S, 33.17

Price and Availability

Size Price Availability Quantity
25mg USD 365 2 weeks
50mg USD 625 2 weeks
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Synonym: ACM-504847; ACM504847; ACM 504847; CCG-38863; CCG38863; CCG 38863; KB-50554; KB50554; KB 50554; Erysolin

IUPAC/Chemical Name: 1-isothiocyanato-4-(methylsulfonyl)butane

InChi Key: WNCZPWWLBZOFJL-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H11NO2S2/c1-11(8,9)5-3-2-4-7-6-10/h2-5H2,1H3

SMILES Code: O=S(CCCCN=C=S)(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 193.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PubMed PMID: 20944144.

2: Lamy E, Schröder J, Paulus S, Brenk P, Stahl T, Mersch-Sundermann V. Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action. Food Chem Toxicol. 2008 Jul;46(7):2415-21. doi: 10.1016/j.fct.2008.03.022. Epub 2008 Apr 1. PubMed PMID: 18479797.

3: Doudican NA, Bowling B, Orlow SJ. Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism. Leuk Res. 2010 Feb;34(2):229-34. doi: 10.1016/j.leukres.2009.05.017. Epub 2009 Jun 21. PubMed PMID: 19540589; PubMed Central PMCID: PMC2815001.

4: Dornberger K, Böckel V, Heyer J, Schönfeld CH, Tonew M, Tonew E. [Investigations of the isothiocyanates erysolin and sulforaphan of Cardaria draba L]. Pharmazie. 1975 Dec;30(12):792-6. German. PubMed PMID: 1219798.

5: Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P. Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 2014 Dec 15;74(24):7534-45. doi: 10.1158/0008-5472.CAN-14-2650. Epub 2014 Oct 21. PubMed PMID: 25336189; PubMed Central PMCID: PMC4268153.

6: Tseng E, Kamath A, Morris ME. Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine. Pharm Res. 2002 Oct;19(10):1509-15. PubMed PMID: 12425469.

7: Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B. Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J. 1995 Oct 15;311 ( Pt 2):453-9. PubMed PMID: 7487881; PubMed Central PMCID: PMC1136021.

8: Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2399-403. PubMed PMID: 1549603; PubMed Central PMCID: PMC48665.

9: Kim SH, Singh SV. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1946-54. doi: 10.1158/1535-7163.MCT-09-0104. Epub 2009 Jul 7. PubMed PMID: 19584240; PubMed Central PMCID: PMC2779717.