MMPP

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H526392

CAS#: 1895957-18-2

Description: MMPP is a novel potent inhibitor of pro-inflammatory responses by inhibiting in vitro STAT3 activation and its downstream signalling in murine macrophages and human synoviocytes from patients with RA.

Chemical Structure

img
MMPP
CAS# 1895957-18-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H526392
Name: MMPP
CAS#: 1895957-18-2
Chemical Formula: C17H18O3
Exact Mass: 270.13
Molecular Weight: 270.328
Elemental Analysis: C, 75.53; H, 6.71; O, 17.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MMPP

IUPAC/Chemical Name: (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl)phenol

InChi Key: YXLMKJHTTWBHRD-HWKANZROSA-N

InChi Code: InChI=1S/C17H18O3/c1-19-15-9-6-13(7-10-15)4-3-5-14-8-11-16(18)17(12-14)20-2/h3,5-12,18H,4H2,1-2H3/b5-3+

SMILES Code: OC1=CC=C(/C=C/CC2=CC=C(OC)C=C2)C=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Nagasawa S, Sasano Y, Iwabuchi Y. Catalytic Oxygenative Allylic Transposition of Alkenes into Enones Realized by an Azaadamantane-Type Oxoammonium Salt Catalyst. Chemistry. 2017 Jun 3. doi: 10.1002/chem.201702512. [Epub ahead of print] PubMed PMID: 28577334.

2: Park CW, Song YS, Lee HP, Hong JT, Yoon DY. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol induces apoptosis in HeLa cervical cancer cells via the extrinsic apoptotic pathway. J Microbiol Biotechnol. 2017 May 17. doi: 10.4014/jmb.1703.03060. [Epub ahead of print] PubMed PMID: 28511296.

3: Zheng J, Son DJ, Lee HL, Lee HP, Kim TH, Joo JH, Ham YW, Kim WJ, Jung JK, Han SB, Hong JT. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol suppresses ovarian cancer cell growth via inhibition of ERK and STAT3. Mol Carcinog. 2017 Mar 9. doi: 10.1002/mc.22648. [Epub ahead of print] PubMed PMID: 28277616.

4: Son DJ, Kim DH, Nah SS, Park MH, Lee HP, Han SB, Venkatareddy U, Gann B, Rodriguez K, Burt SR, Ham YW, Jung YY, Hong JT. Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3. Sci Rep. 2016 Nov 15;6:36852. doi: 10.1038/srep36852. PubMed PMID: 27845373; PubMed Central PMCID: PMC5109275.

5: Liu H, Mei X, Zhang Z, Sun J. Mini-midvastus versus mini-medial parapatellar approach in simultaneous bilateral total knee arthroplasty with 24-month follow-up. Acta Orthop Traumatol Turc. 2015;49(6):586-92. doi: 10.3944/AOTT.2015.15.0078. PubMed PMID: 26511683.

6: Temperini A, Curini M, Rosati O, Minuti L. Magnesium bis(monoperoxyphthalate) hexahydrate as mild and efficient oxidant for the synthesis of selenones. Beilstein J Org Chem. 2014 Jun 2;10:1267-71. doi: 10.3762/bjoc.10.127. eCollection 2014. PubMed PMID: 24991278; PubMed Central PMCID: PMC4077369.

7: Navarrete A, Flores-Machorro FX, Téllez-Ballesteros RI, Alfaro-Romero A, Balderas JL, Reyes A. Study on action mechanism of 1-(4-methoxy-2-methylphenyl)piperazine (MMPP) in acquisition, formation, and consolidation of memory in mice. Drug Dev Res. 2014 Mar;75(2):59-67. doi: 10.1002/ddr.21094. Epub 2013 Aug 2. PubMed PMID: 24648132.

8: Manfredini R, Fabbian F, Manfredini F, Salmi R, Gallerani M, Bossone E. Chronobiology in aortic diseases - "is this really a random phenomenon?". Prog Cardiovasc Dis. 2013 Jul-Aug;56(1):116-24. doi: 10.1016/j.pcad.2013.04.001. Epub 2013 May 23. Review. PubMed PMID: 23993245.

9: Cuesta-Vargas AI, Buchan J, Arroyo-Morales M. A multimodal physiotherapy programme plus deep water running for improving cancer-related fatigue and quality of life in breast cancer survivors. Eur J Cancer Care (Engl). 2014 Jan;23(1):15-21. doi: 10.1111/ecc.12114. Epub 2013 Aug 16. PubMed PMID: 23947581.

10: Heekin RD, Fokin AA. Mini-midvastus versus mini-medial parapatellar approach for minimally invasive total knee arthroplasty: outcomes pendulum is at equilibrium. J Arthroplasty. 2014 Feb;29(2):339-42. doi: 10.1016/j.arth.2013.05.016. Epub 2013 Jun 19. PubMed PMID: 23790343.

11: Thayakaran R, Ramesh NI. Markov modulated Poisson process models incorporating covariates for rainfall intensity. Water Sci Technol. 2013;67(8):1786-92. doi: 10.2166/wst.2013.056. PubMed PMID: 23579834.

12: Salvador JA, Moreira VM, Pinto RM, Leal AS, Paixão JA. Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives. Beilstein J Org Chem. 2012;8:164-9. doi: 10.3762/bjoc.8.17. Epub 2012 Jan 30. PubMed PMID: 22423283; PubMed Central PMCID: PMC3302076.

13: Horejsh D, Kampf G. Efficacy of three surface disinfectants against spores of Clostridium difficile ribotype 027. Int J Hyg Environ Health. 2011 Mar;214(2):172-4. doi: 10.1016/j.ijheh.2010.10.004. Epub 2010 Dec 4. PubMed PMID: 21134785.

14: Toporisic R, Mlakar A, Hvala J, Prislan I, Zupancic-Kralj L. Identification of new impurities of enalapril maleate on oxidation in the presence of magnesium monoperoxyphthalate. J Pharm Biomed Anal. 2010 Jun 5;52(2):294-9. doi: 10.1016/j.jpba.2009.12.018. Epub 2009 Dec 29. PubMed PMID: 20122808.

15: Jäger M, Kiel A, Herten DP, Hamprecht FA. Analysis of single-molecule fluorescence spectroscopic data with a Markov-modulated Poisson process. Chemphyschem. 2009 Oct 5;10(14):2486-95. doi: 10.1002/cphc.200900331. PubMed PMID: 19644999.

16: Inami K, Okazawa M, Mochizuki M. Mutagenicity of aromatic amines and amides with chemical models for cytochrome P450 in Ames assay. Toxicol In Vitro. 2009 Sep;23(6):986-91. doi: 10.1016/j.tiv.2009.06.025. Epub 2009 Jun 27. PubMed PMID: 19563884.

17: Chandrasekhar V, Nagarajan L, Clérac R, Ghosh S, Senapati T, Verma S. Barrel- and crown-shaped dodecanuclear copper(II) cages built from phosphonate, pyrazole, and hydroxide ligands. Inorg Chem. 2008 Jun 16;47(12):5347-54. doi: 10.1021/ic800509f. Epub 2008 May 17. PubMed PMID: 18484717.

18: Pèpe G, Courcambeck J, Perbost R, Jouanna P, Halfon P. Prediction of HIV-1 protease inhibitor resistance by Molecular Modeling Protocols (MMPs) using GenMol software. Eur J Med Chem. 2008 Nov;43(11):2518-34. doi: 10.1016/j.ejmech.2008.02.046. Epub 2008 Mar 14. PubMed PMID: 18455274.

19: Chandrasekhar V, Azhakar R, Senapati T, Thilagar P, Ghosh S, Verma S, Boomishankar R, Steiner A, Kögerler P. Synthesis, structure, magnetism and nuclease activity of tetranuclear copper(II) phosphonates containing ancillary 2,2'-bipyridine or 1,10-phenanthroline ligands. Dalton Trans. 2008 Mar 7;(9):1150-60. doi: 10.1039/b712876b. Epub 2008 Jan 7. PubMed PMID: 18283376.

20: Chandrasekhar V, Nagarajan L, Clérac R, Ghosh S, Verma S. A distorted cubic tetranuclear copper(II) phosphonate cage with a double-four-ring-type core. Inorg Chem. 2008 Feb 4;47(3):1067-73. doi: 10.1021/ic701948g. Epub 2008 Jan 10. PubMed PMID: 18183972.