SLUPP-225

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H530672

CAS#: Unknown

Description: SLUPP-225 is an efflux pump inhibitor (EPI) having the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. SLUPP-225 interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli. SLUPP-225 demonstrates favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, and potentiation of the activity of novobiocin and erythromycin.

Chemical Structure

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SLUPP-225
CAS# Unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H530672
Name: SLUPP-225
CAS#: Unknown
Chemical Formula: C18H16ClN3O
Exact Mass: 325.10
Molecular Weight: 325.796
Elemental Analysis: C, 66.36; H, 4.95; Cl, 10.88; N, 12.90; O, 4.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SLUPP-225; SLUPP 225; SLUPP225.

IUPAC/Chemical Name: (E)-3-(2-Chlorophenyl)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl)acrylamide

InChi Key: XXDLJQNMGHYILE-JXMROGBWSA-N

InChi Code: InChI=1S/C18H16ClN3O/c19-16-4-2-1-3-13(16)7-10-17(23)22-15-8-5-14(6-9-15)18-20-11-12-21-18/h1-10H,11-12H2,(H,20,21)(H,22,23)/b10-7+

SMILES Code: O=C(NC1=CC=C(C2=NCCN2)C=C1)/C=C/C3=CC=CC=C3Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 325.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry JY,
Rybenkov VV, Smith JC, Walker JK. Identification and Structure-Activity
Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in
Escherichia coli. J Med Chem. 2017 Jun 26. doi: 10.1021/acs.jmedchem.7b00453.
[Epub ahead of print] PubMed PMID: 28650638.