WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530672
CAS#: Unknown
Description: SLUPP-225 is an efflux pump inhibitor (EPI) having the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. SLUPP-225 interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli. SLUPP-225 demonstrates favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, and potentiation of the activity of novobiocin and erythromycin.
Hodoodo Cat#: H530672
Name: SLUPP-225
CAS#: Unknown
Chemical Formula: C18H16ClN3O
Exact Mass: 325.10
Molecular Weight: 325.796
Elemental Analysis: C, 66.36; H, 4.95; Cl, 10.88; N, 12.90; O, 4.91
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Synonym: SLUPP-225; SLUPP 225; SLUPP225.
IUPAC/Chemical Name: (E)-3-(2-Chlorophenyl)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl)acrylamide
InChi Key: XXDLJQNMGHYILE-JXMROGBWSA-N
InChi Code: InChI=1S/C18H16ClN3O/c19-16-4-2-1-3-13(16)7-10-17(23)22-15-8-5-14(6-9-15)18-20-11-12-21-18/h1-10H,11-12H2,(H,20,21)(H,22,23)/b10-7+
SMILES Code: O=C(NC1=CC=C(C2=NCCN2)C=C1)/C=C/C3=CC=CC=C3Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 325.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry JY,
Rybenkov VV, Smith JC, Walker JK. Identification and Structure-Activity
Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in
Escherichia coli. J Med Chem. 2017 Jun 26. doi: 10.1021/acs.jmedchem.7b00453.
[Epub ahead of print] PubMed PMID: 28650638.