WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407502
CAS#: 1030021-40-9 (HCl)
Description: CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. CMP-5 shows promise as a novel therapeutic approach for B-cell lymphomas.
Hodoodo Cat#: H407502
Name: CMP-5 HCl
CAS#: 1030021-40-9 (HCl)
Chemical Formula: C21H22ClN3
Exact Mass: 0.00
Molecular Weight: 351.878
Elemental Analysis: C, 71.68; H, 6.30; Cl, 10.07; N, 11.94
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Related CAS #: 1030021-40-9 (HCl) 880813-42-3 (free base)
Synonym: CMP5; CMP-5; CMP 5; CMP5 HCl; CMP5 hydrochloride.
IUPAC/Chemical Name: 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride.
InChi Key: LTMOFUKBECEABM-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21N3.ClH/c1-2-24-20-9-4-3-8-18(20)19-13-16(10-11-21(19)24)14-22-15-17-7-5-6-12-23-17;/h3-13,22H,2,14-15H2,1H3;1H
SMILES Code: CCN1C2=C(C3=C1C=CC=C3)C=C(CNCC4=NC=CC=C4)C=C2.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: PRMT5 is the predominant type II PRMT and in association with the WD-repeat-containing protein MEP50 (methylosome protein 50) forms large multimolecular complexes with different binding partners. PRMT5 is postulated to have a relationship with cell growth, cell cycle progression, cell death, and cell proliferation. PRMT5 was validated as an anticancer target in mantle cell lymphoma (MCL) and glioblastoma.
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The following data is based on the product molecular weight 351.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
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Alinari, L.; Mahasenan, K. V.; Yan, F.; Karkhanis, V.; Chung, J. H.; Smith, E. M.; Quinion, C.; Smith, P. L.; Kim, L.; Patton, J. T.; Lapalombella, R.; Yu, B.; Wu, Y.; Roy, S.; De Leo, A.; Pileri, S.; Agostinelli, C.; Ayers, L.; Bradner, J. E.; Chen-Kiang, S.; Elemento, O.; Motiwala, T.; Majumder, S.; Byrd, J. C.; Jacob, S.; Sif, S.; Li, C.; Baiocchi, R. A. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood 2015, 125, 2530−2543.