WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561197
CAS#: 1185388-35-5
Description: A110 is a potent and selective inhibitor of IMPDHs. A110 binds to the NAD(+) cofactor site and forms a ternary complex with IMP.
Hodoodo Cat#: H561197
Name: A110
CAS#: 1185388-35-5
Chemical Formula: C19H15ClN4O2
Exact Mass: 366.09
Molecular Weight: 366.810
Elemental Analysis: C, 62.22; H, 4.12; Cl, 9.66; N, 15.27; O, 8.72
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Synonym: A110; A 110; A-110
IUPAC/Chemical Name: (R)-4-(1-(1-(4-Chlorophenyl)-1H-1,2,3-triazol-4-yl)ethoxy)quinoline 1-oxide
InChi Key: SVKHERCOWKMPQO-CYBMUJFWSA-N
InChi Code: InChI=1S/C19H15ClN4O2/c1-13(17-12-23(22-21-17)15-8-6-14(20)7-9-15)26-19-10-11-24(25)18-5-3-2-4-16(18)19/h2-13H,1H3/t13-/m1/s1
SMILES Code: C[C@H](C1=CN(C2=CC=C(Cl)C=C2)N=N1)OC3=C4C=CC=CC4=[N+]([O-])C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 366.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wei Y, Kuzmič P, Yu R, Modi G, Hedstrom L. Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics. Biochemistry. 2016 Sep 20;55(37):5279-88. doi: 10.1021/acs.biochem.6b00265. Epub 2016 Sep 2. PubMed PMID: 27541177; PubMed Central PMCID: PMC5524190.