WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561214
CAS#: 918311-87-2
Description: UCL2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker. UCL2077 suppresses the sAHP present in hippocampal neurons in culture and in the slice preparation. UCL2077 is selective and has minimal effects on Ca(2+) channels, action potentials, input resistance and the medium afterhyperpolarization.
Hodoodo Cat#: H561214
Name: UCL2077
CAS#: 918311-87-2
Chemical Formula: C25H22N2
Exact Mass: 350.18
Molecular Weight: 350.470
Elemental Analysis: C, 85.68; H, 6.33; N, 7.99
Synonym: UCL2077, UCL 2077, UCL-2077
IUPAC/Chemical Name: 1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine
InChi Key: PQFNWDHABGBCHB-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2
SMILES Code: C1(C(NCC2=CN=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 350.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Shah MM, Javadzadeh-Tabatabaie M, Benton DC, Ganellin CR, Haylett DG. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502. Epub 2006 Jul 28. PubMed PMID: 16877678; PubMed Central PMCID: PMC2346772.
2: Soh H, Tzingounis AV. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95. doi: 10.1124/mol.110.066100. Epub 2010 Sep 15. PubMed PMID: 20843955; PubMed Central PMCID: PMC2993466.
3: Zaitsev AV, Anwyl R. Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex. J Neurophysiol. 2012 Jan;107(1):205-15. doi: 10.1152/jn.00452.2011. Epub 2011 Oct 5. PubMed PMID: 21975445.
4: Ishibashi M, Gumenchuk I, Miyazaki K, Inoue T, Ross WN, Leonard CS. Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. J Neurosci. 2016 Sep 28;36(39):10097-115. doi: 10.1523/JNEUROSCI.0635-16.2016. Epub 2016 Sep 28. PubMed PMID: 27683906; PubMed Central PMCID: PMC5039256.
5: Lee K, Duan W, Sneyd J, Herbison AE. Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons. J Neurosci. 2010 May 5;30(18):6214-24. doi: 10.1523/JNEUROSCI.6156-09.2010. PubMed PMID: 20445047.
6: Zhang L, Kolaj M, Renaud LP. Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors. J Neurophysiol. 2010 Oct;104(4):2052-62. doi: 10.1152/jn.00320.2010. Epub 2010 Aug 18. PubMed PMID: 20719929.
7: Zhang L, Renaud LP, Kolaj M. Properties of a T-type Ca2+channel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons. J Neurophysiol. 2009 Jun;101(6):2741-50. doi: 10.1152/jn.91183.2008. Epub 2009 Mar 25. PubMed PMID: 19321637.
