WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571006
CAS#: 2508-89-6
Description: Duazomycin is an antitumor substance and glutamine antagonist, used as a chemotherapeutic agent.
Hodoodo Cat#: H571006
Name: Duazomycin
CAS#: 2508-89-6
Chemical Formula: C8H11N3O4
Exact Mass: 213.08
Molecular Weight: 213.190
Elemental Analysis: C, 45.07; H, 5.20; N, 19.71; O, 30.02
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Duazomycin, Diazomycin A, Duazomycin A, Acetyl-don, NSC 51097
IUPAC/Chemical Name: Norleucine, N-acetyl-6-diazo-5-oxo-, L-
InChi Key: WBSWOKCKZUNHQV-ZETCQYMHSA-N
InChi Code: InChI=1S/C8H11N3O4/c1-5(12)11-7(8(14)15)3-2-6(13)4-10-9/h4,7H,2-3H2,1H3,(H,11,12)(H,14,15)/t7-/m0/s1
SMILES Code: O=C(O)[C@H](CCC(C=[N+]=[N-])=O)NC(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
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The following data is based on the product molecular weight 213.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: ROSENBERG S, CALABRESI P. ENHANCED SUPPRESSION OF THE SECONDARY IMMUNE RESPONSE BY COMBINATION OF 6-MERCAPTOPURINE DUAZOMYCIN A'. Nature. 1963 Sep 14;199:1101-2. PubMed PMID: 14066954.
2: Kaplan SR, Hayslett JP, Calabresi P. Treatment of advanced Wegener's granulomatosis with azathioprine and duazomycin A. N Engl J Med. 1968 Feb 1;278(5):239-44. PubMed PMID: 5635457.
3: Vogel CL, Calabresi P. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine. Proc Soc Exp Biol Med. 1969 May;131(1):251-6. PubMed PMID: 5770114.
4: Foley HT, Shnider BI, Gold GL, Rius J. A pilot study of methotrexate, duazomycin A, and radiation therapy in carcinoma of the lung. J New Drugs. 1966 Mar-Apr;6(2):105-11. PubMed PMID: 5331283.
5: Lefkowitz ER, Creasey WA, Calabresi P, Sartorelli AC. Clinical and pharmacologic effects of combinations of 6-thioguanine and duazomycin A in patients with neoplastic disease. Cancer Res. 1965 Sep;25(8):1207-12. PubMed PMID: 5839715.
6: Colsky J, Shnider BI, Franzino A, Perez J. Observations in patients with metastatic malignancy treated with duazomycin A. Clin Pharmacol Ther. 1966 May-Jun;7(3):352-8. PubMed PMID: 4957007.
7: ANDERSON EP, BROCKMAN RW. BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. Biochem Pharmacol. 1963 Dec;12:1335-54. PubMed PMID: 14096421.
