WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571019
CAS#: 68072-84-4
Description: A 121 is a non-polyene antifungal antibiotic, produced by an unidentified strain of Streptomyces. It is active against a number of filamentous fungi including some plant and human pathogens. The presence of an alpha-ketol system in the molecule is required for A 121 to exhibit antibiotic properties.
Hodoodo Cat#: H571019
Name: A 121
CAS#: 68072-84-4
Chemical Formula: C18H30O5
Exact Mass: 326.21
Molecular Weight: 326.430
Elemental Analysis: C, 66.23; H, 9.26; O, 24.51
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Synonym: A 121
IUPAC/Chemical Name: 1-(2,3-dimethyl-2-(2-methylbut-3-en-2-yl)-2,3-dihydrofuran-3-yl)-3,5-dihydroxy-4-methoxyhexan-2-one
InChi Key: BSIAHHIPMGVHJM-UHFFFAOYSA-N
InChi Code: 1S/C18H30O5/c1-8-16(3,4)18(6)17(5,9-10-23-18)11-13(20)14(21)15(22-7)12(2)19/h8-10,12,14-15,19,21H,1,11H2,2-7H3
SMILES Code: CC(C(C(C(=O)CC1(C=COC1(C)C(C)(C)C=C)C)O)OC)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 326.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Singh S, Samanta TB. A121--an antifungal compound from Streptomyces species. Microbios. 1992;71(288-289):217-24. PubMed PMID: 1479922.
2: Singh SK, Samanta TB. A121--a new antifungal antibiotic. Indian J Exp Biol. 1978 Jun;16(6):708-10. PubMed PMID: 700804.