WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561248
CAS#: 56600-73-8 (racemic)
Description: MDK-0738, also known as AKR1C3-IN-14a, is a potent and selective aldo-keto reductase 1C3 inhibitor. The name MDK-0738 uses the last four digits of the CAS registry number for this compound. MDK-0738 displays selectivity for AKR1C3 over other AKR1C enzymes and COX.
Hodoodo Cat#: H561248
Name: MDK-0738
CAS#: 56600-73-8 (racemic)
Chemical Formula: C15H16O3
Exact Mass: 244.11
Molecular Weight: 244.290
Elemental Analysis: C, 73.75; H, 6.60; O, 19.65
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Related CAS #: 56600-73-8 (racemic)
Synonym: MDK-0738; MDK-0738; MDK-0738; AKR1C3-IN-14a; AKR1C3 IN 14a
IUPAC/Chemical Name: (R)-2-(6-Methoxynaphthalen-2-yl)butanoic acid
InChi Key: LSDAHSHHKKHOKE-CQSZACIVSA-N
InChi Code: InChI=1S/C15H16O3/c1-3-14(15(16)17)12-5-4-11-9-13(18-2)7-6-10(11)8-12/h4-9,14H,3H2,1-2H3,(H,16,17)/t14-/m1/s1
SMILES Code: CC[C@H](C1=CC=C2C=C(OC)C=CC2=C1)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Adeniji A, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM. Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. J Med Chem. 2016 Aug 25;59(16):7431-44. doi: 10.1021/acs.jmedchem.6b00160. Epub 2016 Aug 12. PubMed PMID: 27486833; PubMed Central PMCID: PMC5149398.