Benomyl
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Hodoodo CAT#: H561266

CAS#: 17804-35-2

Description: Benomyl is a is a fungicide. It is a systemic benzimidazole fungicide that is selectively toxic to microorganisms and invertebrates, especially earthworms. Benomyl binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation. The selective toxicity of benomyl as a fungicide is possibly due to its heightened effect on fungal rather than mammalian microtubules.


Chemical Structure

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Benomyl
CAS# 17804-35-2

Theoretical Analysis

Hodoodo Cat#: H561266
Name: Benomyl
CAS#: 17804-35-2
Chemical Formula: C14H18N4O3
Exact Mass: 290.14
Molecular Weight: 290.320
Elemental Analysis: C, 57.92; H, 6.25; N, 19.30; O, 16.53

Price and Availability

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1g USD 180 2 weeks
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Synonym: Benomyl; Benlate; Fundazol; Agrocit; Uzgen

IUPAC/Chemical Name: Methyl N-[1-(butylcarbamoyl)benzimidazol-2-yl]carbamate

InChi Key: RIOXQFHNBCKOKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)

SMILES Code: O=C(OC)NC1=NC2=CC=CC=C2N1C(NCCCC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 290.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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6: Van Gestel CA. Validation of earthworm toxicity tests by comparison with field studies: a review of benomyl, carbendazim, carbofuran, and carbaryl. Ecotoxicol Environ Saf. 1992 Apr;23(2):221-36. Review. PubMed PMID: 1374328.

7: Padilla PA, Ladage ML. Suspended animation, diapause and quiescence: arresting the cell cycle in C. elegans. Cell Cycle. 2012 May 1;11(9):1672-9. doi: 10.4161/cc.19444. Epub 2012 May 1. Review. PubMed PMID: 22510566; PubMed Central PMCID: PMC3372386.

8: Singh P, Rathinasamy K, Mohan R, Panda D. Microtubule assembly dynamics: an attractive target for anticancer drugs. IUBMB Life. 2008 Jun;60(6):368-75. doi: 10.1002/iub.42. Review. PubMed PMID: 18384115.

9: Perreault SD, Linder RE, Strader LF, Slott V. The value of multiple endpoint data in male reproductive toxicology: revelations in the rat. Prog Clin Biol Res. 1989;302:179-92. Review. PubMed PMID: 2666988.

10: Doores S. The microbiology of apples and apple products. Crit Rev Food Sci Nutr. 1983;19(2):133-49. Review. PubMed PMID: 6380951.

11: Hess RA. Effects of environmental toxicants on the efferent ducts, epididymis and fertility. J Reprod Fertil Suppl. 1998;53:247-59. Review. PubMed PMID: 10645284.

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13: Willshaw HE. How dangerous a world is it? Br J Ophthalmol. 1998 Jan;82(1):6-7. Review. PubMed PMID: 9536871; PubMed Central PMCID: PMC1722344.

14: Berger B, von Holst C. Pesticide residues in products of plant origin in the European Union. Sampling strategy and results from the co-ordinated EU monitoring programmes in 1996 and 1997. Environ Sci Pollut Res Int. 2001;8(2):109-12. Review. PubMed PMID: 11400636.

15: Richmond DV. Effects of toxicants on the morphology and fine structure of fungi. Adv Appl Microbiol. 1975;19:289-319. Review. PubMed PMID: 1103589.

16: Moye HA. High speed liquid chromatography of pesticides. J Chromatogr Sci. 1975 Jun;13(6):268-79. Review. PubMed PMID: 806608.

17: Sandhu SS, Waters MD. Mutagenicity evaluation of chemical pesticides. J Environ Sci Health B. 1980;15(6):929-48. Review. PubMed PMID: 7002993.

18: Goedicke HJ. [Toxicological evaluation of pesticide and chemical residues in control of biological processes in vegetables under glass and plastics]. Nahrung. 1988;32(6):565-70. Review. German. PubMed PMID: 3068546.

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20: Papadopoulou-Mourkidou E. Postharvest-applied agrochemicals and their residues in fresh fruits and vegetables. J Assoc Off Anal Chem. 1991 Sep-Oct;74(5):745-65. Review. PubMed PMID: 1783584.